Dual-energy CT Aortography with 50% Reduced Iodine Dose Versus Single-energy CT Aortography with Standard Iodine Dose

Treatment planning based on water density image generated using dual‐energy computed tomography for pancreatic cancer with contrast‐enhancing agent: Phantom and clinical study

“…In this study, we first demonstrated that the WDI could relieve the effect of the contrast‐enhancing agent on dose distributions better than the VMI at 77 keV, which provided the equivalent HU values with the conventional SECT image . The effect of iodine on dose distribution was larger in the TP VMI than that in the TP WDI , and the effect was more prominent when the doses were calculated by more sophisticated dose calculation algorithms.…”

“…In this study, we first demonstrated that the WDI could relieve the effect of the contrast-enhancing agent on dose distributions better than the VMI at 77 keV, which provided the equivalent HU values with the conventional SECT image. [15][16][17] The effect of iodine on dose distribution was larger in the TP VMI than that in the TP WDI , and the effect was more prominent when the doses were calculated by more sophisticated dose calculation algorithms. For clinical cases, the difference in the dosimetric parameter between the TP WDI and the TP VMI was significantly larger when the doses were calculated by using more sophisticated dose calculation algorithms.…”

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

“…Reduced iodine dose at DECT angiography is also valuable to patients with aortic and peripheral vascular disease because such patients frequently have co-existing renal disease, as is the case in diabetics, patients with a history of smoking, and those with advanced atherosclerotic disease. Current DECT angiographic protocols that use reduced contrast material may require as little as half the contrast material dose required for SECT[86]. …”

“…Contrast-enhanced CT imaging was quickly adopted as the first-line test for a wide range of critical clinical decisions. As examples, contrast-enhanced CT is essential for patient triage in the emergency setting [2], and also for accurate high-resolution anatomic staging and treatment monitoring of cancer [3], systemic diseases, and vascular disease [4, 5], among others.…”

“…DECT, and future generations of spectral CT scanners, provide the ability to not only detect a given reporter element such as iodine [4], but also to distinguish between different reporter elements when multiple contrast agents with different reporter elements are delivered simultaneously or near-simultaneously into the body [18–22]. Our review will cover the basics of DECT and PCED CT technology and the rapidly changing understanding of contrast material usage with DECT, summarize published research on non-iodinated and non-barium agents that could become profoundly useful in the new age of spectral CT, and explore patient-safety challenges that new CT contrast agent development will face.…”