Dual-energy contrast-enhanced spectral mammography (CESM)

Daniaux, Martin; Zordo, Tobias De; Santner, Wolfram; Amort, Birgit; Koppelstätter, Florian; Jaschke, Werner; Dromain, Clarisse; Oberaigner, Willi; Hubalek, Michael; Marth, Christian

doi:10.1007/s00404-015-3693-2

Cited by 46 publications

(31 citation statements)

References 23 publications

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“…Indeed, CESM could be immediately available in the mammography suite with minimal loss of time [9]. Therefore, CESM might be an alternative cost-effective imaging method for MRI, especially when MRI availability is limited [9]. Contrast enhanced mammography is emerging as a combined application of full-field digital mammography with intravenous injection of iodinated contrast medium.…”

Section: Discussionmentioning

confidence: 99%

“…There is enthusiasm regarding the potential for CESM to be superior to conventional mammography, through the extended information obtained from contrast media with existing mammography capacity and experience, it could be possibly comparable with MRI, yet more easily accessible. Indeed, CESM could be immediately available in the mammography suite with minimal loss of time [9]. Therefore, CESM might be an alternative cost-effective imaging method for MRI, especially when MRI availability is limited [9].…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic performance of contrast-enhanced spectral mammography: Systematic review and meta-analysis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of contrast-enhanced spectral mammography: Systematic review and meta-analysis

et al. 2016

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“…46 Despite this notable improvement in sensitivity, the specificity for the probability of malignancy remains about the same as conventional mammography, which is approximately 50 to 68%. 46, 47 To address the relatively poor specificity, one needs to establish the correlation between the quantitative information from contrast-enhanced mammograms and the pathological parameters of malignant lesions. However, standard contrast-enhanced spectral mammography technique relies on the weighted log-subtraction of the dual-energy images.…”

Section: Introductionmentioning

confidence: 99%

Quantitative contrast‐enhanced spectral mammography based on photon‐counting detectors: A feasibility study

Ding

Molloi

2017

Medical Physics

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Purpose To investigate the feasibility of accurate quantification of iodine mass thickness in contrast-enhanced spectral mammography. Materials and Methods A computer simulation model was developed to evaluate the performance of a photon-counting spectral mammography system in the application of contrast-enhanced spectral mammography. A figure-of-merit (FOM), which was defined as the decomposed iodine signal-to-noise ratio (SNR) with respect to the square root of the mean glandular dose (MGD), was chosen to optimize the imaging parameters, in terms of beam energy, splitting energy, and pre-filtrations for breasts of various thicknesses and densities. Experimental phantom studies were also performed using a beam energy of 40 kVp and a splitting energy of 34 keV with 3 mm Al pre-filtration. A two-step calibration method was investigated to quantify the iodine mass thickness, and was validated using phantoms composed of a mixture of glandular and adipose materials, for various breast thicknesses and densities. Finally, the traditional dual-energy log-weighted subtraction method was also studied as a comparison. The measured iodine signal from both methods was compared to the known value to characterize the quantification accuracy and precision. Results The optimal imaging parameters, which lead to the highest FOM, were found at a beam energy between 42 to 46 kVp with a splitting energy at 34 keV. The optimal tube voltage decreased as the breast thickness or the Al pre-filtration increased. The proposed quantification method was able to measure iodine mass thickness on phantoms of various thicknesses and densities with high accuracy. The root-mean-square (RMS) error for cm-scale lesion phantoms was estimated to be 0.20 mg/cm2. The precision of the technique, characterized by the standard deviation of the measurements, was estimated to be 0.18 mg/cm2. The traditional weighted subtraction method also predicted a linear correlation between the measured signal and the known iodine mass thickness. However, the correlation slope and offset values were strongly dependent on the total breast thickness and density. Conclusion The results of the current study suggest that iodine mass thickness for cm-scale lesions can be accurately quantified with contrast-enhanced spectral mammography. The quantitative information can potentially improve the differential power for malignancy.

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“…Another application of such phantoms is in testing, evaluation and clarification of the role and the benefits of new x-ray modalities in comparative studies to actual daily routine. Breast tomosynthesis (Sechopoulos 2013), contrast-enhanced mammography (Francescone et al 2014, Daniaux et al 2015, as well as new imaging modalities to be potentially established like breast computed tomography (CT) (Lindfors et al 2008, Mettivier and Russo 2011, Kalender et al 2012, Sarno et al 2015, dual-energy breast CT (Badr et al 2014) and phase-contrast breast imaging (Bravin et al 2013, Auweter et al 2014, Sarno et al 2017a are being explored.…”

Section: Introductionmentioning

confidence: 99%

Suitability of low density materials for 3D printing of physical breast phantoms

et al. 2018

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Breast physical phantoms are a basic tool for the assessment and verification of performance standards in daily clinical practice of x-ray breast imaging modalities. They are also invaluable in testing and evaluation of new x-ray breast modalities to be potentially established, e.g. breast computed tomography, dual-energy breast CT and phase-contrast mammography and tomography. Nowadays, there is a lack or there are only a limited number of breast physical phantoms available for this purpose.The aim of this study is to explore a range of 3D printing materials such as resins, PLA, ABS, Nylon etc, to determine their attenuation and refractive properties, and to finally compare them to the properties of the breast tissues: adipose, glandular and skin.To achieve this goal, step-wedge phantoms were computationally modeled and then manufactured using stereolithographic and fused-deposition modeling technologies. X-ray images of the phantoms were acquired, using monochromatic beam at ID17, ESRF, Grenoble for three energies-30 keV, 45 keV and 60 keV. Experimental data were further processed to obtain the linear attenuation coefficients of these materials. Comparison with theoretical data for the linear attenuation coefficients and the refractive indexes for breast tissues was performed.From the studied materials, most of the resins, Nylon, Hybrid, PET-G show absorption properties close to the glandular tissue, while ABS shows absorption characteristics close to these of the adipose tissue. For phase-contrast imaging, it turns out that the ABS combined with resin-based materials to represent the adipose and glandular tissues, respectively may be a good combination for manufacturing of a phantom suitable for these studies.These results can be used for the design and the construction of a new physical anthropomorphic phantom of the breast with improved anatomical and radiological characteristics dedicated for advanced mammography imaging techniques implemented at higher photon energies.

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Dual-energy contrast-enhanced spectral mammography (CESM)

Cited by 46 publications

References 23 publications

Diagnostic performance of contrast-enhanced spectral mammography: Systematic review and meta-analysis

Diagnostic performance of contrast-enhanced spectral mammography: Systematic review and meta-analysis

Quantitative contrast‐enhanced spectral mammography based on photon‐counting detectors: A feasibility study

Suitability of low density materials for 3D printing of physical breast phantoms

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