Dual-elemental analysis of single particles using quadrupole-based inductively coupled plasma-mass spectrometry

Chun, Ka-Him; Lum, Judy Tsz-Shan; Leung, Kwong Sak

doi:10.1016/j.aca.2021.339389

Cited by 16 publications

(12 citation statements)

References 47 publications

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“…In fact, a few reports on monitoring of two isotopes from the same nanoparticle event with q-ICP-MS have been published already, 61,106 and the two most recent ones have made use of gas addition in the cell for stretching the signal corresponding to each NP. 107,108 In any case, it is important to keep this aspect in mind when optimizing the method to ensure conditions in which the integrity of the signal corresponding to every individual event can be preserved and recorded.…”

Section: Chemical Science Accepted Manuscriptmentioning

confidence: 99%

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

et al. 2022

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Section: Chemical Science Accepted Manuscriptmentioning

confidence: 99%

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

et al. 2022

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“… − As an economical alternative to these existing techniques, quadrupole-based inductively coupled plasma mass spectrometry (ICP-MS) is a promising method for quantifying nanoscale interactions . Researchers have used single cell ICP-MS (SC-ICP-MS) to probe nanoparticle interactions with algae, yeast, and bacteria. − Other studies using SC-ICP-MS investigated intrinsic metals, metallodrugs, and nanoparticles within various human cell lines. − In this report, we demonstrated that quadrupole SC-ICP-MS detected metal-tagged human B cells at a rate of ∼30 cells per second with a 50% transport efficiency. We quantified model gold nanoparticles (AuNPs) within single B cells and further demonstrated that >80% of B cells had internalized AuNPs.…”

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confidence: 87%

Absolute Quantification of Nanoparticle Interactions with Individual Human B Cells by Single Cell Mass Spectrometry

et al. 2022

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We report on the absolute quantification of nanoparticle interactions with individual human B cells using quadrupolebased inductively coupled plasma mass spectrometry (ICP-MS). This method enables the quantification of nanoparticle−cell interactions at single nanoparticle and single cell levels. We demonstrate the efficient and accurate detection of individually suspended B cells and found an ∼100-fold higher association of colloidally stable positively charged nanoparticles with single B cells than neutrally charged nanoparticles. We confirmed that these nanoparticles were internalized by individual B cells and determined that the internalization occurred via energy-dependent pathways consistent with endocytosis. Using dual analyte ICP-MS, we determined that >80% of single B cells were positive for nanoparticles. Our study demonstrates an ICP-MS workflow for the absolute quantification of nanoparticle−cell interactions with single cell and single nanoparticle resolution. This unique workflow could inform the rational design of various nanomaterials for controlling cellular interactions, including immune cell−nanoparticle interactions.

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“…Although the increase in acquisition time and peak-jumping enables for multi-element analysis of single particle to some extent, it was observed that the multiple detection is still limited to at most two targeted elements in each NP [69]. The recent study performed dual-mass measurement of individual particles using quadrupole-based ICP-MS (ICP-QMS) [79]. This type of detection is usually called as "quasi-simultaneous" analysis of NP composition concerning 2 elements/isotopes due to the high frequency of time-mass scanning.…”

Section: Determination Of the Elemental And Isotopic Composition Of Npsmentioning

confidence: 99%

“…This type of detection is usually called as "quasi-simultaneous" analysis of NP composition concerning 2 elements/isotopes due to the high frequency of time-mass scanning. Nevertheless, the lack of acquisition data in long settling time, i.e., time separating the measurements of two consecutive masses which corresponds to time required for stabilizing the quadrupole, leads to loss of signal and measurement of incomplete events [4,[79][80][81]. Concerning settling time, in order to allow sufficient value for the quadrupole, the analysis should be focused on the detection of two isotopes with close m/z ratio, and where the difference between two isotopes should be smaller than 20 mass units [79].…”

Section: Determination Of the Elemental And Isotopic Composition Of Npsmentioning

confidence: 99%

“…Nevertheless, the lack of acquisition data in long settling time, i.e., time separating the measurements of two consecutive masses which corresponds to time required for stabilizing the quadrupole, leads to loss of signal and measurement of incomplete events [4,[79][80][81]. Concerning settling time, in order to allow sufficient value for the quadrupole, the analysis should be focused on the detection of two isotopes with close m/z ratio, and where the difference between two isotopes should be smaller than 20 mass units [79]. Heetpat et al applied SP-ICP-MS with simultaneous dual-mode detector for bimetallic NP analysis to determine Au core size and Ag shell thickness [82].…”

Section: Determination Of the Elemental And Isotopic Composition Of Npsmentioning

confidence: 99%

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Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Borowska

Jankowski

2023

Anal Bioanal Chem

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The use of engineered nanoparticles in the environment and human life has increased in the last 20 years. The risk assessment concerning application of nanomaterials in biological systems requires their thorough characterization. Understanding the correlations between physicochemical properties of nanoparticles concerning not only the size, particle size distribution, number concentration, degree of aggregation, or agglomeration but also solubility, stability, binding affinity, surface activity, chemical composition, and nanoparticle synthesis yield allows their reliable characterization. Thus, to find the structure-function/property relationship of nanoparticles, multifaceted characterization approach based on more than one analytical technique is required. On the other hand, the increasing demand for identification and characterization of nanomaterials has contributed to the continuous development of spectrometric techniques which enables for their qualitative and quantitative analysis in complex matrices giving reproducible and reliable results. This review is aimed at providing a discussion concerning four main aspects of nanoparticle characterization: nanoparticle synthesis yield, particle size and number concentration, elemental and isotopic composition of nanoparticles, and their surface properties. The conventional and non-conventional spectrometric techniques such as spectrophotometry UV-Vis, mass spectrometric techniques working in conventional and single-particle mode, or those based on optical emission detection systems are described with special emphasis paid on their advantages and drawbacks. The application and recent advances of these methods are also comprehensively reviewed and critically discussed. Graphical abstract

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Dual-elemental analysis of single particles using quadrupole-based inductively coupled plasma-mass spectrometry

Cited by 16 publications

References 47 publications

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

Absolute Quantification of Nanoparticle Interactions with Individual Human B Cells by Single Cell Mass Spectrometry

Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

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