Dual EGFR/ErbB3 targeting effectively inhibits tumor progression in pancreatic ductal adenocarcinoma (PDAC)

Azih, Lilian C.; Arnoletti, J. Pablo; Liles, J. Spencer; Heslin, Martin J.; Mikhailina, Alvetina; Frolov, Andrey

doi:10.1016/j.jamcollsurg.2011.06.343

Cited by 1 publication

(2 citation statements)

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“…And, the inhibition of the formation of NETs and the blockade of IL‐1β can effectively attenuate the EGFR‐induced progression of pancreatic cancer. A previous study showed that IL‐1β could activate EGFR via the CXCL1‐CXCR2 axis in oral cancers 51 . It has also been reported that IL‐1 drives breast cancer growth and bone metastasis in vivo 52 .…”

Section: Discussionmentioning

confidence: 95%

“…In our study, anti‐IL‐1β antibodies abolished NETs‐induced EMT by blocking the EGFR/ERK pathway. It has been reported that EGFR affects the progression of pancreatic cancer through a variety of signalling pathways 51 . And, the inhibition of the formation of NETs and the blockade of IL‐1β can effectively attenuate the EGFR‐induced progression of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil extracellular DNA traps promote pancreatic cancer cells migration and invasion by activating EGFR/ERK pathway

Jin

Yin

et al. 2021

J Cellular Molecular Medi

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Neutrophil extracellular DNA traps (NETs) are newly discovered forms of activated neutrophils. Increasing researches have shown that NETs play important roles in cancer progression. Our previous study has proved that tumour‐infiltrating NETs could predict postsurgical survival in patients with pancreatic ductal adenocarcinoma (PDAC). However, the roles of NETs on the progression of pancreatic cancer are unknown. Here, we investigated the effects of NETs on pancreatic cancer cells. Results showed that both PDAC patients’ and normal individuals’ neutrophils‐derived NETs could promote migration and invasion of pancreatic cancer cells with epithelial‐mesenchymal transition. Further, study confirmed that EGFR/ERK pathway played an important role in this progression. The addition of neutralizing antibodies for IL‐1β could effectively block the activation of EGFR/ERK companied with reduction of EMT, migration and invasion. Taken together, NETs facilitated EMT, migration and invasion via IL‐1β/EGFR/ERK pathway in pancreatic cancer cells. Our study suggests that NETs may provide promising therapeutic targets for pancreatic cancer.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%