Dual effects of natural killer cells in transplantation for leukemia

Arima, Nobuyoshi

doi:10.1016/j.critrevonc.2020.103206

Cited by 4 publications

(3 citation statements)

References 96 publications

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“…5 year event free survival rate in recipients of KIR-HLA incompatible transplants was 60%, compared to 5% in KIR-HLA compatible recipients (p<0.0005), suggesting an enormous impact of NK-mediated killing of AML in an HLA-mismatch dependent manner. The effect of KIR-HLA mismatch on transplant outcomes in AML is an ongoing area of intense research ( 76 – 78 ).…”

Section: Nk Cells In Amlmentioning

confidence: 99%

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Kent,

Crump,

Davila

2023

Front. Immunol.

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Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of research in myeloid neoplasms given their remarkable success in other hematologic malignancies, particularly B-cell-derived acute lymphoid leukemia, myeloma, and lymphomas. Several limitations have hindered clinical application of adoptive cell therapies in AML including lack of leukemia-specific antigens, on-target-off-leukemic toxicity, immunosuppressive microenvironments, and leukemic stem cell populations elusive to immune recognition and destruction. While there are promising T cell-based therapies including chimeric antigen receptor (CAR)-T designs under development, other cytotoxic lymphocyte cell subsets have unique phenotypes and capabilities that might be of additional benefit in AML treatment. Of particular interest are the natural killer (NK) and unconventional T cells known as invariant natural killer T (iNKT) and gamma delta (γδ) T cells. NK, iNKT, and γδT cells exhibit intrinsic anti-malignant properties, potential for alloreactivity, and human leukocyte-antigen (HLA)-independent function. Here we review the biology of each of these unconventional cytotoxic lymphocyte cell types and compare and contrast their strengths and limitations as the basis for adoptive cell therapies for AML.

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Section: Nk Cells In Amlmentioning

confidence: 99%

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Kent,

Crump,

Davila

2023

Front. Immunol.

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“…NK cells can discriminate between allogeneic cells and self and have robust cytolytic effector mechanisms to establish as much effector response as possible, even without previous immune sensitization [90]. Unlike lymphocytes, NK cells can be stimulated even without MHC molecules.…”

Section: Natural Killer (Nk) Cellsmentioning

confidence: 99%

Classic and Current Opinions in Human Organ and Tissue Transplantation

Oli¹,

Rowaiye²,

Adejumo³

et al. 2022

Cureus

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Graft tolerance is a pathophysiological condition heavily reliant on the dynamic interaction of the innate and adaptive immune systems. Genetic polymorphism determines immune responses to tissue/organ transplantation, and intricate humoral and cell-mediated mechanisms control these responses. In transplantation, the clinician's goal is to achieve a delicate equilibrium between the allogeneic immune response, undesired effects of the immunosuppressive drugs, and the existing morbidities that are potentially life-threatening. Transplant immunopathology involves sensitization, effector, and apoptosis phases which recruit and engages immunological cells like natural killer cells, lymphocytes, neutrophils, and monocytes. Similarly, these cells are involved in the transfer of normal or genetically engineered T cells. Advances in tissue transplantation would involve a profound knowledge of the molecular mechanisms that underpin the respective immunopathology involved and the design of precision medicines that are safe and effective.

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“…These receptors–ligands pairs have been described extensively in several reviews that cover both murine and human NK cell features, and their detailed description is beyond the scope of this review. Recent reports can be consulted for a more comprehensive description of these characteristics [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. Briefly, activating or inhibiting receptors can be found on NK cells [ 56 , 57 , 58 , 59 ], and their engagement eventually results in the killing or the protection from the killing of the target cell [ 56 , 57 , 58 , 59 ].…”

Section: Basic Interaction Between Natural Killer Cells and Tumor Cellsmentioning

confidence: 99%

Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages

Poggi

Villa

Fernadez

et al. 2021

Cancers

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Several approaches have shown that the immune response against tumors strongly affects patients’ clinical outcome. Thus, the study of anti-tumor immunity is critical to understand and potentiate the mechanisms underlying the elimination of tumor cells. Natural killer (NK) cells are members of innate immunity and represent powerful anti-tumor effectors, able to eliminate tumor cells without a previous sensitization. Thus, the study of their involvement in anti-tumor responses is critical for clinical translation. This analysis has been performed in vitro, co-incubating NK with tumor cells and quantifying the cytotoxic activity of NK cells. In vivo confirmation has been applied to overcome the limits of in vitro testing, however, the innate immunity of mice and humans is different, leading to discrepancies. Different activating receptors on NK cells and counter-ligands on tumor cells are involved in the antitumor response, and innate immunity is strictly dependent on the specific microenvironment where it takes place. Thus, three-dimensional (3D) culture systems, where NK and tumor cells can interact in a tissue-like architecture, have been created. For example, tumor cell spheroids and primary organoids derived from several tumor types, have been used so far to analyze innate immune response, replacing animal models. Herein, we briefly introduce NK cells and analyze and discuss in detail the properties of 3D tumor culture systems and their use for the study of tumor cell interactions with NK cells.

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Dual effects of natural killer cells in transplantation for leukemia

Cited by 4 publications

References 96 publications

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Classic and Current Opinions in Human Organ and Tissue Transplantation

Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages

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