Dual Effects of Lsd, Mescaline and DMT

Bridger, Wagner H.

doi:10.1016/b978-0-08-021938-7.50015-1

Cited by 3 publications

(1 citation statement)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that neophobia and agoraphobia are distinguishable, yet are affected by LSD in the same direction, suggests that LSD produces a more general intensification of reactivity to threatening situations. Similar conclusions have been drawn by others (Bridger, Barr, Gibbons, & Gorelick, 1978; Freedman & Halaris, 1978).…”

Section: Discussionsupporting

confidence: 92%

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

Adams¹,

Geyer²

1985

Behavioral Neuroscience

View full text Add to dashboard Cite

The utility of various measures of exploratory activity in rats was studied in order to develop an animal model of hallucinogens. A hole board chamber, connected by a door to a home cage, provided two test situations. Rats either were placed directly into the hole board with the door closed (forced exploration) or were placed in the home cage and, following adaptation, the door was opened (free exploration). The monitoring system provided both quantitative measures (crossovers, rearings, and hole pokes) and qualitative measures of locomotor patterns. A series of four experiments, with doses of 2-160 micrograms/kg LSD, revealed three major categories of effects, distinguishable on the basis of dose dependency, time course, or response to environmental manipulation: increased avoidance of novel and central areas, disruption of the spatial patterning of locomotion, and suppression of rearing. All three effects exhibited partial tolerance 24 hr after one injection of 30 micrograms/kg LSD and complete tolerance after five daily injections. The possibility that LSD's enhancement of neophobia in rats may be a valid analogue model of its intensification of affective reactions in humans is discussed.

show abstract

Section: Discussionsupporting

confidence: 92%

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

Adams¹,

Geyer²

1985

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

The role of hallucinogenic drugs and sensory stimuli in Peruvian ritual healing

Joralemon

1984

Cult Med Psych

View full text Add to dashboard Cite

On Peru's north coast, curanderos perform night-long curing ceremonies in which the mescaline-bearing cactus San Pedro is used. The concept of autonomic nervous system tuning is presented as the best explanation for the overall physiological effect of the ritual. An assessment of the possible therapeutic impact of this condition is provided. Organic response and symbolic message are seen to resonate in the purificatory connotations of the ritual.

show abstract

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

Adams

Geyer²

1985

Behavioral Neuroscience

View full text Add to dashboard Cite

Dual Effects of Lsd, Mescaline and DMT

Cited by 3 publications

References 120 publications

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

The role of hallucinogenic drugs and sensory stimuli in Peruvian ritual healing

A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.

Contact Info

Product

Resources

About