2000
DOI: 10.1006/taap.2000.9011
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Dual Effect of Tamoxifen, an Anti-Breast-Cancer Drug, on Intracellular Ca2+ and Cytotoxicity in Intact Cells

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Cited by 13 publications
(23 citation statements)
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“…This value is similar to the 10 lM observed in breast cancer cells, bladder cancer cells and renal tubular cells (Chang et al 2001(Chang et al , 2002Jan et al 2000). Tamoxifen increased [Ca 2+ ] i by releasing store-Ca 2+ and causing Ca 2+ influx because removing extracellular Ca 2+ partly reduced the tamoxifen-induced [Ca 2+ ] i increase.…”
Section: Discussionsupporting
confidence: 84%
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“…This value is similar to the 10 lM observed in breast cancer cells, bladder cancer cells and renal tubular cells (Chang et al 2001(Chang et al , 2002Jan et al 2000). Tamoxifen increased [Ca 2+ ] i by releasing store-Ca 2+ and causing Ca 2+ influx because removing extracellular Ca 2+ partly reduced the tamoxifen-induced [Ca 2+ ] i increase.…”
Section: Discussionsupporting
confidence: 84%
“…However, evidence accumulates that tamoxifen expresses additional effects such as inducing an immediate increase in [Ca 2+ ] i in several cell types in a manner unrelated to estrogen receptors. These cell types include renal tubular cells, bladder cancer cells, neutrophils, prostate cancer cells and glioma cells (Chang et al 2001(Chang et al , 2002Jan et al 2000). Because an unregulated [Ca 2+ ] i increase can alter many cell functions, the [Ca 2+ ] i -elevating effect of tamoxifen in cells from different tissues may be associated with the diverse in vivo effects of tamoxifen in different tissues.…”
Section: Discussionmentioning
confidence: 98%
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