Dual effect of adrenalin on sugar transport in rat diaphragm muscle

Bihler, I.; Sawh, P.C.; Sloan, I.G.

doi:10.1016/0005-2736(78)90035-4

Cited by 43 publications

(18 citation statements)

References 20 publications

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Section: Discussionmentioning

confidence: 88%

“…The stimulatory effect of epinephrine was seen on the basal nonstimulated glucose uptake, was mediated by (3- (12,13), but not in rat soleus muscle (14). At more physiological concentrations (10 nM-0.1 uM), however, the catecholamine has been noted to exert an inhibitory effect (12,13). Unless there is a gross difference between the epinephrine sensitivity of rat diaphragm and skeletal muscle, these findings lend further support to the idea that muscle is not the site of the stimulatory effect of 10 nM-0.1 ,uM epinephrine on glucose uptake observed in the present study.3 Epinephrine was observed by early investigators to stimulate glucose uptake by adipose tissue (27,28).…”

Section: Discussionmentioning

confidence: 99%

“…Newsholme and Randle (12) reported that epinephrine at 0.1 mM moderately increased the uptake of D-3-0-methylglucose, but not D-xylose in diaphragm. More recently, Bihler and associates (13,14) demonstrated an inhibitory effect of 10 nM-10 ,uM epinephrine on the transport of 3-0-methylglucose in rat diaphragm and soleus. At very high concentrations (0.1-1 mM) the catecholamine was reported to stimulate transport of the hexose in diaphragm, but not soleus (13,14).…”

Section: Introductionmentioning

confidence: 97%

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Inhibitory Effect of Epinephrine on Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle

Chiasson¹,

Shikama²,

Chu³

et al. 1981

J. Clin. Invest.

169

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A B S T R A C T The effect of epinephrine on basal and insulin-stimulated glucose uptake in perfused hindlimbs offed rats was studied. Insulin increased glucose uptake in a dose-dependent manner from a basal value of 1.5+0.3 up to a maximum value of 5.3 ±0.9 ,umol/min per 100 g with 6 nM (1 mU/ml). Epinephrine at 10 nM and 0.1 ,uM also increased glucose uptake to 2.6±0.1 and 3.1±0.1 ,mol/min per 100 g, respectively. These same concentrations of epinephrine, however, suppressed the insulin-stimulated glucose uptake to 3.2±0.3 Amol/min per 100 g. Both the stimulatory and inhibitory effects of epinephrine on glucose uptake were completely reversed by propranolol, but were not significantly altered by phentolamine.Uptake of 3-O-methylglucose and 2-deoxyglucose into thigh muscles of the perfused hindlimbs was stimulated fivefold by insulin, but was unaffected by epinephrine. Epinephrine also did not inhibit the stimulation of uptake by insulin. Epinephrine decreased the phosphorylation of 2-deoxyglucose, however, and caused the intracellular accumulation of free glucose. These last two effects were more prominent in the presence of insulin. Whereas epinephrine caused large rises in glucose-6-P and fructose-6-P, insulin did not alter the concentration of these metabolites either in the absence or presence ofepinephrine.These data indicate that: (a) epinephrine has a stimulatory effect on glucose uptake by perfused rat hindlimbs that does not appear to be exerted on skeletal muscle; (b) epinephrine does not affect hexose transport in skeletal muscle; (c) epinephrine inhibits insulinstimulated glucose uptake in skeletal muscle by inhibiting glucose phosphorylation. It is hypothesized that the inhibition of glucose phosphorylation is due to the stimulation of glycogenolysis, which leads to the Dr. Chiasson's present address is

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Inhibitory Effect of Epinephrine on Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle

Chiasson¹,

Shikama²,

Chu³

et al. 1981

J. Clin. Invest.

169

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“…Both calcium and cyclic (c) AMP have been implicated in the regulation of the uptake of sugar in various tissues (4)(5)(6)(7)(8)(9)(10). In addition, thyroid hormone has been demonstrated to affect both calcium (11)(12)(13) and cAMP (14)(15)(16)(17)(18) metabolism in different tissues.…”

Section: Introductionmentioning

confidence: 99%

Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate.

Segal¹,

Ingbar²

1981

J. Clin. Invest.

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A B S T R A C T The present experiments were designed to explore the mechanism whereby 3,5,3'-triiodothyronine (T3) stimulates the uptake of 2-deoxy-D-glucose (2-DG) in rat thymocytes in vitro. Addition of T3 evoked a transient, dose-related increase in cellular cyclic (c) AMP concentrations, evident within 5 min, followed soon by an increase in 2-DG uptake. The effects of T3 on both cAMP concentration and 2-DG uptake were dependent upon the presence of extracellular calcium. Epinephrine also induced a sequential increase in thymocyte cAMP concentration and 2-DG uptake. These responses were more prompt than those to T3, but were calcium independent. As with their combined effects on 2-DG uptake, T3 and epinephrine produced synergistic or additive effects on cellular cAMP concentration. Dibutyryl cAMP also stimulated 2-DG uptake, an effect that was more prompt than that of epinephrine, and, like that of epinephrine, was calcium independent.Prior or simultaneous addition of L-alprenolol (10 AM), which, we have previously shown, blocks the effect of both T3 and epinephrine on 2-DG uptake, also blocked the increase in thymocyte cAMP concentration induced by these agents. In contrast, Lalprenolol failed to block the increase in 2-DG uptake produced by dibutyryl cAMP. On the basis of these observations we suggest that T3 increases 2-DG uptake in the rat thymocyte by increasing the cellular concentration of cAMP, which then acts to enhance sugar transport. The increase in 2-DG uptake induced by epinephrine is also mediated by an increase in cAMP concentration. The greater

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“…Newsholme and Randle [36] reported that 66 PM epinephrine increased the uptake of D-3-0-methylglucose, but not D-xylose in diaphragm. In 1978, Bihler and colleagues [37,38] reported that 10 nM-10 PM epinephrine inhibited the transport of 3-0-methylglucose in rat diaphragm and soleus. However, at very high concentrations (0.1-l mM) transport was stimulated in diaphragm [37].…”

mentioning

confidence: 99%

Co‐ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via α‐receptors

et al. 1983

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Dual effect of adrenalin on sugar transport in rat diaphragm muscle

Cited by 43 publications

References 20 publications

Inhibitory Effect of Epinephrine on Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle

Inhibitory Effect of Epinephrine on Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle

Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate.

Co‐ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via α‐receptors

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