Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration

Zou, Fei; Lv, Feizhou; Ma, Xiaosheng; Xia, Xinlei; Cai, Liang; Mei, Shiqi; Wei, Jie; Niu, Yunfei; Jiang, Jianyuan

doi:10.1016/j.matdes.2019.108433

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…Biofunctionalization is a surface chemical modification technique that allows the immobilization of biofunctional molecules (lipids, proteins, nucleic acid, and carbohydrates) on the material surface to achieve control of the tissue–implant interface by biomimicking it, thus improving adhesion of cells, platelets, bacteria, and the absorption of proteins, peptides, antibodies and DNA, and the response cell (Figure ). ,,,, Therefore, in recent years different biofunctionalization techniques have been used for improving osteogenic activity and mechanical compatibility. ,, …”

Section: Materials Biofunctionalizationmentioning

confidence: 99%

Microalgae Applications to Bone Repairing Processes: A Review

Payares

Púa

Pareja

et al. 2023

ACS Biomater. Sci. Eng.

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Research on regeneration and accelerated recovery processes of bone tissue has driven a growing interest in the scientific community. Implementing natural materials to reduce rejections due to biocompatibility issues is an important trend. Biofunctionalization processes have been proposed to promote osseointegration in implant materials, and those substances able to generate an adequate environment for cell proliferation are the object of several studies. Because of their high protein content and their anti-inflammatory, antibacterial, antimicrobial, and healing properties, microalgae represent a natural source of bioactive compounds, and are proposed as candidates for tissue regeneration applications. In this paper microalgae are reviewed as a source of biofunctionalized materials focused on orthopedic applications.

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Section: Materials Biofunctionalizationmentioning

confidence: 99%

Microalgae Applications to Bone Repairing Processes: A Review

Payares

Púa

Pareja

et al. 2023

ACS Biomater. Sci. Eng.

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“…Similarly, curcumin-loaded cellulose-epichlorohydrin-zinc oxide hybrid hydrogels were developed and were evaluated to determine their antifungal and antibacterial effects against Trichophyton rubrum and Staphylococcus aureus. Excellent antifungal and antibacterial effects were observed with the designed curcumin hydrogels, showing their anti-infective potential against skin infections [120,121]. Another curcumin-loaded thermosensitive hydrogel was developed, and its activity was assessed in rats.…”

Section: Hydrogelsmentioning

confidence: 99%

“…The results demonstrated that the double-loading of drugs provided the materials with good antibacterial and osteogenic activity. Additionally, indeed, the addition of curcumin and genistein to the nanoporous coating conferred high antibacterial activity against S. aureus and E. coli and promoted the in vitro proliferation and differentiation of rat bone mesenchymal stem cells, both effects being particularly desirable for orthopedic applications [121]. Very recently, Lee et al developed a novel bioactive bone substitute with antibiofilm activity by functionalizing hydroxyapatite with curcumin.…”

Section: Curcumin In Orthopedics: Antibacterial and Osteogenic Effectsmentioning

confidence: 99%

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

et al. 2022

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Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential. In combination therapy with other phytochemicals, curcumin shows synergistic effects, and this approach appears to be suitable for the eradication of antibiotic-resistant microbes and promising for achieving co-loaded antimicrobial pro-regenerative coatings for orthopedic implant biomaterials. Poor water solubility, low bioavailability, and rapid degradation are the main disadvantages of curcumin. The use of nanotechnologies for the delivery of curcumin could increase the prospects for its clinical application, mainly in orthopedics and other surgical scenarios. Curcumin-loaded nanoparticles revealed antimicrobial properties against S. aureus in periprosthetic joint infections.

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“…In the two natural extracts, the antibacterial activity mainly comes from the slow release of CR from the porous coating, while GT primarily plays a role in promoting osteogenesis. 28…”

Section: Curcuminmentioning

confidence: 99%

“…The results of in vitro antibacterial experiments showed that S. aureus and E. coli on the material's surface decreased by 99.62% and 98.59%, respectively. In the two natural extracts, the antibacterial activity mainly comes from the slow release of CR from the porous coating, while GT primarily plays a role in promoting osteogenesis 28 …”

Section: Antibacterial Coatingmentioning

confidence: 99%

Modification strategies for improving antibacterial properties of polyetheretherketone

Gao

Han

et al. 2022

J of Applied Polymer Sci

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Polyetheretherketone (PEEK) is a semi‐crystalline thermoplastic polymer that has been gradually used in the repair of bone defects because of its well chemical stability, reliable biocompatibility, excellent X‐ray radiolucency, and low modulus. However, PEEK is a biologically inert material, and planktonic bacteria can adhere to its surface and eventually form biofilms, allowing for the rapid development of implant‐related infections. This review mainly introduces two important antibacterial modification strategies: antibacterial coating and surface morphology modification. Antibacterial coating include antibiotics, natural extracts, antimicrobial peptides, polymers, metals and metal oxides, selenium, fluoride, silicon nitride, and graphene oxide. These coatings can exert their antibacterial effect by inhibiting bacterial adhesion, killing bacteria by contact, or actively releasing antimicrobial substances. In terms of antibacterial surface topography, different surface microstructures have their respective antibacterial functions. Conical or cylindrical structures can exert stress on the bacterial surface causing the rupture of the cell membrane to kill bacteria. Nano protrusions or particles smaller than the size of bacteria can inhibit the adhesion of bacteria by reducing the contact area of bacteria and PEEK. The pit structure close to the size of bacteria can prevent the contact between adjacent bacteria and delay or prevent the formation of biofilm.

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Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration

Cited by 12 publications

References 30 publications

Microalgae Applications to Bone Repairing Processes: A Review

Microalgae Applications to Bone Repairing Processes: A Review

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

Modification strategies for improving antibacterial properties of polyetheretherketone

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