Dual-drug loaded ultrasound-responsive nanodroplets for on-demand combination chemotherapy

Spatarelu, Catalina-Paula; Jandhyala, Sidhartha; Luke, Geoffrey P.

doi:10.1016/j.ultras.2023.107056

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…In addition to facilitating imaging, ultrasound can also stimulate the release of the material transported by the nanocarrier, i.e., the drug and the MRI agent [42,43], as well as affecting cell uptake [29]. Much research has focused attention on the development of various ultrasound-sensitive nanodroplets, showing their potential in drug delivery and targeting, as well as in imaging [44][45][46]. Here, the theranostic companions are represented by PLP and the MRI agent Gd-DTPAMA-CHOL (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study

et al. 2023

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This paper describes a novel nanoformulation for dual MRI/US in vivo monitoring of drug delivery/release. The nanosystem was made of a perfluoropentane core coated with phospholipids stabilized by glycol chitosan crosslinked with triphosphate ions, and it was co-loaded with the prodrug prednisolone phosphate (PLP) and the structurally similar MRI agent Gd-DTPAMA-CHOL. Importantly, the in vitro release of PLP and Gd-DTPAMA-CHOL from the nanocarrier showed similar profiles, validating the potential impact of the MRI agent as an imaging reporter for the drug release. On the other hand, the nanobubbles were also detectable by US imaging both in vitro and in vivo. Therefore, the temporal evolution of both MRI and US contrast after the administration of the proposed nanosystem could report on the delivery and the release kinetics of the transported drug in a given lesion.

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Section: Discussionmentioning

confidence: 99%

Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study

et al. 2023

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“…This first iteration of breast cancer hyperthermia has been shown to augment chemotherapy, radiation therapy and immunotherapy. The targeted delivery, or the controlled-release, of microbubble or nanodroplet chemo/immunotherapy [ 56 , 57 ], and both thermal- and non-thermal-targeted ablations are envisioned for this exciting new field of theranostic possibilities. Finally, the focusing power exists for TR acoustics to increase temperatures to ablative levels (e.g., >60 °C).…”

Section: The Future Of Dynamic Focusing For Therapymentioning

confidence: 99%

Breast Tomographic Ultrasound: The Spectrum from Current Dense Breast Cancer Screenings to Future Theranostic Treatments

Littrup,

Mehrmohammadi,

Duric

2024

Tomography

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This review provides unique insights to the scientific scope and clinical visions of the inventors and pioneers of the SoftVue breast tomographic ultrasound (BTUS). Their >20-year collaboration produced extensive basic research and technology developments, culminating in SoftVue, which recently received the Food and Drug Administration’s approval as an adjunct to breast cancer screening in women with dense breasts. SoftVue’s multi-center trial confirmed the diagnostic goals of the tissue characterization and localization of quantitative acoustic tissue differences in 2D and 3D coronal image sequences. SoftVue mass characterizations are also reviewed within the standard cancer risk categories of the Breast Imaging Reporting and Data System. As a quantitative diagnostic modality, SoftVue can also function as a cost-effective platform for artificial intelligence-assisted breast cancer identification. Finally, SoftVue’s quantitative acoustic maps facilitate noninvasive temperature monitoring and a unique form of time-reversed, focused US in a single theranostic device that actually focuses acoustic energy better within the highly scattering breast tissues, allowing for localized hyperthermia, drug delivery, and/or ablation. Women also prefer the comfort of SoftVue over mammograms and will continue to seek out less-invasive breast care, from diagnosis to treatment.

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“…This gives an extra level of control that can be leveraged to boost US contrast . Third, they can be loaded with optical dyes, nanoparticles, or therapeutic molecules for multimodal imaging or image-guided drug delivery. ,− …”

mentioning

confidence: 99%

Multiplex Ultrasound Imaging of Perfluorocarbon Nanodroplets Enabled by Decomposition of Postvaporization Dynamics

Van Namen,

Jandhyala,

Spatarelu

et al. 2023

Nano Lett.

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Despite the real-time, nonionizing, and costeffective nature of ultrasound imaging, there is a dearth of methods to visualize two or more populations of contrast agents simultaneously�a technique known as multiplex imaging. Here, we present a new approach to multiplex ultrasound imaging using perfluorocarbon (PFC) nanodroplets. The nanodroplets, which undergo a liquid-to-gas phase transition in response to an acoustic trigger, act as activatable contrast agents. This work characterized the dynamic responses of two PFC nanodroplets with boiling points of 28 and 56 °C. These characteristic responses were then used to demonstrate that the relative concentrations of the two populations of PFC nanodroplets could be accurately measured in the same imaging volume within an average error of 1.1%. Overall, the findings indicate the potential of this approach for multiplex ultrasound imaging, allowing for the simultaneous visualization of multiple molecular targets simultaneously.

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Dual-drug loaded ultrasound-responsive nanodroplets for on-demand combination chemotherapy

Cited by 10 publications

References 45 publications

Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study

Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study

Breast Tomographic Ultrasound: The Spectrum from Current Dense Breast Cancer Screenings to Future Theranostic Treatments

Multiplex Ultrasound Imaging of Perfluorocarbon Nanodroplets Enabled by Decomposition of Postvaporization Dynamics

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