Dual drug loaded polyhydroxy butyric acid/gelatin nanofibrous scaffold for possible post-surgery cancer treatment

Ramanathan, Giriprasath; Thangavelu, Muthukumar; Felciya, Sekar Jeyakumar Grace; Uma, T.

doi:10.1016/j.matlet.2022.132597

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…In this study, about 30% of HPW release occurred within 24 h and attained 78% after 60 h, indicating a faster release of collagen in the treated group than that in the untreated groups. The sustained release of drugs can improve the healing process and prolong the protectiveness against infection and inflammation [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

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Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

2022

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In this study, collagen hydrolysates (CHDs) were fabricated with honey-propolis wax (HPW), structurally modified as a sponge matrix, and experimentalized on wound healing in a mouse model. The scaffold was characterized by means of in vitro enzymatic degradation; in vitro HPW release; and in vivo wound-healing mouse model, wound-healing-specific RNA, transcripts, and protein markers. The functional activity of the HPW extracted from raw propolis was determined using total flavonoids, antioxidant scavenging assays, and anti-hemolytic principles. The results indicated that HPW had a high flavonoid content (20 μg/mL of wax) and antioxidant activities. The effective concentration (EC50) of HPW was estimated (28 mg/mL) and was then used in the subsequent in vivo experiments. Additionally, the dopped mixture of CHDs and HPW substantially enhanced the wound-healing process and regulated wound biochemical markers such as hexoseamine and melondialdehyde. CHDs- HPW upregulated the expression of growth factors including vascular endothelial growth factor (VEGF) (2.3-fold), fibroblast growth factor (FGF) and epidermal growth factor (EGF) (1.7-fold), and transforming growth factor-beta (TGF-β) (3.1-fold), indicating their potential capacity to perform wound re-epithelialization and the loading of ground tissue. Pro-inflammatory markers IL-1 β (51 pg/mL) and TNF-α (220 pg/mL) were significantly reduced in the CHD-HPW-treated wound. These interesting results were further confirmed using mRNA and protein growth factors from the wound, which enhanced the load of collagen-I in the wound site. In conclusion, CHDs-HPW exhibited a significant reduction in inflammation and inflammatory markers and helped to obtain a faster wound-healing process in a mouse model. The newly engineered biosponge could be developed as a promising therapeutic approach for the regeneration and repair of damaged human skin in the future.

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Section: Discussionmentioning

confidence: 99%

“…The enzymatic degradation of the collagen sponge matrix was studied according to Muthukumar and colleagues [ 35 ]. The collagenase enzyme was used to digest the collagen sponge matrix, which was pre-weighed.…”

Section: Methodsmentioning

confidence: 99%

Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

2022

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“…Research has investigated the use of nanofiber scaffolds loaded with two drugs for potential postoperative cancer treatment and demonstrated the potential of this approach for oral cancer therapy [ 95 ]. These scaffolds, such as dual drug-loaded polyhydroxybutyric acid/gelatin nanofibers, have attracted much attention for the treatment of tissue defects after surgery for cancer [ 95 ].…”

Section: Different Types Of Scaffold-based Drug Delivery In Oral Canc...mentioning

confidence: 99%

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy.

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“…They compared the release of two types of drugs having different hydrophilic properties, the highly hydrophilic 5-FU was released first at a higher rate than MT. After 24–96 h, both MT and 5-FU demonstrated a stable release rate that can effectively meet the needs of different types of drugs in the treatment of cancer after surgery ( Ramanathan et al, 2022 ).…”

Section: Properties Of Gelatin For An Anticancer Ddnsmentioning

confidence: 99%

Gelatin-based anticancer drug delivery nanosystems: A mini review

Jiang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery nanosystems (DDnS) is widely developed recently. Gelatin is a high-potential biomaterial originated from natural resources for anticancer DDnS, which can effectively improve the utilization of anticancer drugs and reduce side effects. The hydrophilic, amphoteric behavior and sol-gel transition of gelatin can be used to fulfill various requirements of anticancer DDnS. Additionally, the high number of multifunctional groups on the surface of gelatin provides the possibility of crosslinking and further modifications. In this review, we focus on the properties of gelatin and briefly elaborate the correlation between the properties and anticancer DDnS. Furthermore, we discuss the applications of gelatin-based DDnS in various cancer treatments. Overall, we have summarized the excellent properties of gelatin and correlated with DDnS to provide a manual for the design of gelatin-based materials for DDnS.

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Dual drug loaded polyhydroxy butyric acid/gelatin nanofibrous scaffold for possible post-surgery cancer treatment

Cited by 6 publications

References 14 publications

Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Gelatin-based anticancer drug delivery nanosystems: A mini review

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