Dual-drug loaded phase-changing nanodroplets for image-guided tumor therapy

Spatarelu, Catalina-Paula; Jandhyala, Sidhartha; Luke, Geoffrey P.

doi:10.1117/12.2542339

Cited by 1 publication

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of drugs or active compounds that can be encapsulated in our platform, some limitations that could be related to the structure of the drug are to be expected. In a previous study from our group, a different chemotherapeutic, cisplatin, was used as the drug encapsulated in the core, with results showing that its reduced solubility limited the amount that could be loaded . The choice of hydrophobic compound might also depend on its solubility in chloroform, to enable codissolution with the lipids.…”

Section: Resultsmentioning

confidence: 99%

“…In a previous study from our group, a different chemotherapeutic, cisplatin, was used as the drug encapsulated in the core, with results showing that its reduced solubility limited the amount that could be loaded. 61 The choice of hydrophobic compound might also depend on its solubility in chloroform, to enable codissolution with the lipids. Our experience in encapsulating hydrophobic molecules with rather different structures and characteristics, such as paclitaxel, the Epolight dyes showed in the study, as well as other lyphophilic dyes such as DiR and DiD seems promising for the range of compounds that would be suitably loaded onto this type of constructs.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Optically Activatable Double-Drug-Loaded Perfluorocarbon Nanodroplets for On-Demand Image-Guided Drug Delivery

Spatarelu

Namen

Luke

2021

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

Phase-changing nanodroplets have been studied as externally activatable in situ microbubble precursors. The nanodroplets can be triggered to vaporize with an external optical or acoustic energy source, and the resulting microbubbles can be visualized with high sensitivity using ultrasound imaging. Because of their nanoscale size, this type of construct is attractive for the encapsulation and on-site, on-demand release of therapeutics. Here, we develop a double-drug loaded nanodroplet platform that can coencapsulate paclitaxel and doxorubicin, and release them upon external laser activation. Nanodroplets are characterized in terms of size, stability, protein interaction, and drug release. Their capacity to concurrently release the two drugs and generate ultrasound contrast is demonstrated in vitro. The efficacy of dual-drug loaded nanodroplets is compared in vitro with that of free drug formulations, and potential mechanisms of their enhanced cytotoxic behavior are explored. Overall, the results show that the nanodroplets are a versatile platform for on-demand image-guided drug delivery.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%