Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

Abstract

Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactideco-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of the film formulation were achieved utilizing several ratios of excipients, including polyvinyl alcohol, polyethylene glycol, hyaluronic acid, xylitol, and alginate. The scaffold film showed superior encapsulation capability and swelling properties, with various potential applications, eg, the treatment of diabetes-associated complications. Structural and light scattering characterization confirmed a spherical shape and a mean particle size distribution of 41.3 nm for nanoparticles in the scaffold film. Spectroscopy revealed a stable polymer structure before and after encapsulation. The thermoresponsive swelling properties of the film were evaluated according to temperature and pH. Scaffold films incorporating dual drug-loaded nanoparticles showed remarkably high thermoresponsivity, cell compatibility, and ex vivo drug-release behavior. In addition, the hybrid film formulation showed enhanced cell adhesion and proliferation. These dual drugloaded nanoparticles incorporated into a scaffold film may be promising for development into a transdermal drug-delivery system.

Production of encapsulated quercetin particles using supercritical fluid technologies

“…In contrast to that result, in the previous work the spectra of the physical mixture of quercetin / lecithin = 1 / 75 (in mass) [18] showed the characteristic peaks of pure quercetin in the range of 1480-1380, 1200-1100, 880-750 and 600-400 cm -1 [35]. This result could indicate, that although Pluronic L64 ® itself is not able to encapsulate A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 29 quercetin particles, as presented in previous work [18], applying it with soy-bean lecithin a more efficient encapsulation is achieved.…”

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

“…PLGA can be hydrolyzed in the body and yield biodegradable lactic acid and glycolic acid. PLGA nanoparticles have been used as carriers for many phytochemicals such as quercetin and curcumin[60–62]. Those phytochemical can either entrapped inside or adsorbed on the surface of PLGA nanoparticle [63].…”

“…We have successfully synthesized quercetin encapsulated NLCs and found that the aqueous solubility of quercetin increased about 1000-fold (Figure 2). Additionally, a sustained release pattern was observed in quercetin loaded nanoparticles including poly(lactic acid) or PLGA nanoparticles [60,106,107], SLNs and NLCs [108,109]. …”

Eco-friendly Multifunction Petroleum Additives: Preparation, Characterization and Evaluation

“…1400 -1200 cm -1 [39]. SL shows characteristic peaks in the range of 1765 -970 cm -1 (at 1765 -1720 cm -1 corresponding to C=O, 1200 -1145 cm -1 corresponding to P=O, 1145 -970 cm -1 corresponding to P-O-C, and 1200 -970 cm -1 corresponding to (P-O-C and PO 2 ) [40].…”