Dual-drug delivery system based on the hydrogels of alginate and sodium carboxymethyl cellulose for colorectal cancer treatment

Sheng, Yanshan; Gao, Jun; Yin, Zheng‐Zhi; Kang, Jing; Kong, Yong

doi:10.1016/j.carbpol.2021.118325

Cited by 94 publications

(30 citation statements)

References 45 publications

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“…5,6 Therefore, controlled and targeted delivery of chemotherapeutic drugs is of significant importance to the therapy of cancers through minimizing the undesirable damages to the healthy organs. 7 The past decades have witnessed the applications of nanosized carriers in controlled drug delivery. 8 A range of nanosized carrier materials such as mesoporous silica nanoparticles (MSNs), 9,10 Au nanoparticles, 11,12 carbon nanotubes, 13,14 and so on have been widely used for the delivery of chemotherapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid encapsulated aminated mesoporous silica nanoparticles for pH‐responsive delivery of methotrexate and release kinetics

Yin

Cai

et al. 2022

Bulletin Korean Chem Soc

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A simple drug controlled delivery system is facilely designed for pH-responsive delivery of methotrexate (MTX), an anticancer drug. Aminated mesoporous silica nanoparticles (AMSNs) were first synthesized for the loading of MTX, and then the MTX-loaded AMSN (AMSN-MTX) was encapsulated with hyaluronic acid (HA) through electrostatic attractions. Successful preparation of the HAencapsulated AMSN-MTX (AMSN-MTX-HA) is confirmed by different characterizations such as scanning electron microscopy, Fourier transform infrared, x-ray diffraction, and so on. Because the protonation/deprotonation of HA is closely related to pH, the electrostatic interactions between HA and AMSN depend closely on the pH of the medium and thus pH-responsive delivery of MTX is achieved. The release kinetic data of MTX from the carrier fit well to Higuchi and Korsmeyer-Peppas models. Cell experiments indicate that the developed AMSN-MTX-HA displays high inhibitory effect on hepatoma (SMMC-7721) cells while the drug-free carrier of AMSN-HA has good biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic acid encapsulated aminated mesoporous silica nanoparticles for pH‐responsive delivery of methotrexate and release kinetics

Yin

Cai

et al. 2022

Bulletin Korean Chem Soc

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“…In this regard, an advanced hybrid dual-drug delivery system (DDDs) involving Ca +2 crosslinked hydrogels of alginate and sodium carboxymethyl cellulose is developed. Taking advantage of different pH in small intestine and colorectum, this dual drug delivery system was capable of selective delivery of aspirin and methotrexate-loaded CaCO3 microshperes to their respective target organs [ 120 ] (Fig. 5 A).Given TME feature of CRC such as high temperature and acidic pH, dual bioresponsvie pH/thermo-sensitive hydrogels loaded with DOX and curcumin (Fig.…”

Section: Advanced Strategies For Crc Drug Deliverymentioning

confidence: 99%

Recent advances in targeted drug delivery systems for resistant colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (MDR) is one of the major obstacles in CRC treatment. Tumor microenvironment plus genomic instability, tumor derived exosomes (TDE), cancer stem cells (CSCs), circulating tumor cells (CTCs), cell-free DNA (cfDNA), as well as cellular signaling pathways are important issues regarding resistance. Since non-targeted therapy causes toxicity, diverse side effects, and undesired efficacy, targeted therapy with contribution of various carriers has been developed to address the mentioned shortcomings. In this paper the underlying causes of MDR and then various targeting strategies including exosomes, liposomes, hydrogels, cell-based carriers and theranostics which are utilized to overcome therapeutic resistance will be described. We also discuss implication of emerging approaches involving single cell approaches and computer-aided drug delivery with high potential for meeting CRC medical needs.

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“…Adenocarcinoma of the colon is considered highly prevalent nowadays which is the second most common cause of cancer related deaths worldwide [ 69 ]. It has been reported that 50,000 deaths alone in US and 20,000 deaths in Italy are caused by colorectal cancer.…”

Section: Role Of Cellulose Derivative In Formulation Of Novel Drug Delivery Systemsmentioning

confidence: 99%

“…A study conducted by Sheng et al, 2021 fabricated blend of CMC and alginate hydrogel dual loaded with methotrexate and aspirin by co-precipitation method for the treatment of colorectal cancer [ 69 ]. The hydrogel protected the anticancer drug methotrexate from being absorbed in the stomach and small intestine and successfully targeted at colorectum.…”

Section: Role Of Cellulose Derivative In Formulation Of Novel Drug Delivery Systemsmentioning

confidence: 99%

Recent Trends in Assessment of Cellulose Derivatives in Designing Novel and Nanoparticulate-Based Drug Delivery Systems for Improvement of Oral Health

et al. 2021

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Natural polymers are revolutionizing current pharmaceutical dosage forms design as excipient and gained huge importance because of significant influence in formulation development and drug delivery. Oral health refers to the health of the teeth, gums, and the entire oral-facial system that allows us to smile, speak, and chew. Since years, biopolymers stand out due to their biocompatibility, biodegradability, low toxicity, and stability. Polysaccharides such as cellulose and their derivatives possess properties like novel mechanical robustness and hydrophilicity that can be easily fabricated into controlled-release dosage forms. Cellulose attracts the dosage design attention because of constant drug release rate from the precursor nanoparticles. This review discusses the origin, extraction, preparation of cellulose derivatives and their use in formulation development of nanoparticles having multidisciplinary applications as pharmaceutical excipient and in drug delivery, as bacterial and plant cellulose have great potential for application in the biomedical area, including dentistry, protein and peptide delivery, colorectal cancer treatment, and in 3D printable dosage forms.

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Dual-drug delivery system based on the hydrogels of alginate and sodium carboxymethyl cellulose for colorectal cancer treatment

Cited by 94 publications

References 45 publications

Hyaluronic acid encapsulated aminated mesoporous silica nanoparticles for pH‐responsive delivery of methotrexate and release kinetics

Hyaluronic acid encapsulated aminated mesoporous silica nanoparticles for pH‐responsive delivery of methotrexate and release kinetics

Recent advances in targeted drug delivery systems for resistant colorectal cancer

Recent Trends in Assessment of Cellulose Derivatives in Designing Novel and Nanoparticulate-Based Drug Delivery Systems for Improvement of Oral Health

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