Dual drug delivery system based on layered double hydroxides/carboxymethyl cellulose-poly ethylene oxide bionanocomposite electrospun fibrous mats: Fabrication, characterization, in-vitro and in-vivo studies

Yoosefi, Sepideh; Rakhshani, Amir; Montazeri, Vahideh; Tavakoli, Mohammad Reza; Aliabadi, Amin; Fatahi, Yousef; Behrouzfar, Helia; Keihankhadiv, Shadi; Darbasizadeh, Behzad; Motasadizadeh, Hamidreza; Farhadnejad, Hassan

doi:10.1016/j.ijbiomac.2022.10.087

Cited by 13 publications

(2 citation statements)

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“…Yoosefi et al [ 269 ] designed CMC-PEO bionanocomposite electrospun fibrous mats for wound healing containing ibuprofen (IBU) drug and Mg 2 Al LDH intercalated with vancomycin (LDH-VAN) for simultaneous delivery of analgesic and antibiotic species, respectively. The tensile strength of the fibrous mats was enhanced in the presence of LDH particles in comparison to the control (CMC-PEO mat).…”

Section: Organic Polymers and Layered Double Hydroxides Nanocomposite...mentioning

confidence: 99%

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Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

et al. 2023

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The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug.

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Section: Organic Polymers and Layered Double Hydroxides Nanocomposite...mentioning

confidence: 99%

“… Representative photographs of wounds treated by control, CMC-PEO, and IBU/CMC-PEO, LDH-VAN/CMC-PEO, and LDH-VAN/IBU/CMC-PEO groups on days 0, 3, 7, 10, 14, and 19. (reprinted from Yoosefi et al [ 269 ] with permission of Elsevier). …”

Section: Figurementioning

confidence: 99%