Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers

Hussein, Mohamed A. Mohamady; Güler, Ece; Rayaman, Erkan; Çam, Muhammet Emin; Şahin, Ali; Grinholc, Mariusz; Mansuroglu, Demet Sezgin; Şahin, Yeşim Müge; Gündüz, Oğuzhan; Muhammed, Mamoun; El‐Sherbiny, Ibrahim M.; Megahed, Mosaad

doi:10.1016/j.carbpol.2021.118373

Cited by 74 publications

(44 citation statements)

References 52 publications

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“…Over the past few years, there has been continuous improvement in the performance of PCL by producing hybrid biocomposites. PCL hybrid biocomposites have been developed by various researchers, combining PCL with several other compounds, such as acrylic acid, epoxy, unsaturated polyester, phenolic, vinyl ester, as well as natural fibers [ 137 , 138 , 139 , 140 , 141 , 142 , 143 ]. In this section, the mechanical and thermal properties of PCL hybrid biocomposites are presented.…”

Section: Polycaprolactone-based Hydrid Biocompositesmentioning

confidence: 99%

Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications

et al. 2022

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Recent developments within the topic of biomaterials has taken hold of researchers due to the mounting concern of current environmental pollution as well as scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed to be a great potential biomaterial, especially to the tissue engineering sector, due to its advantages, including its biocompatibility and low bioactivity exhibition. The commercialization of PCL is deemed as infant technology despite of all its advantages. This contributed to the disadvantages of PCL, including expensive, toxic, and complex. Therefore, the shift towards the utilization of PCL as an alternative biomaterial in the development of biocomposites has been exponentially increased in recent years. PCL-based biocomposites are unique and versatile technology equipped with several importance features. In addition, the understanding on the properties of PCL and its blend is vital as it is influenced by the application of biocomposites. The superior characteristics of PCL-based green and hybrid biocomposites has expanded their applications, such as in the biomedical field, as well as in tissue engineering and medical implants. Thus, this review is aimed to critically discuss the characteristics of PCL-based biocomposites, which cover each mechanical and thermal properties and their importance towards several applications. The emergence of nanomaterials as reinforcement agent in PCL-based biocomposites was also a tackled issue within this review. On the whole, recent developments of PCL as a potential biomaterial in recent applications is reviewed.

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Section: Polycaprolactone-based Hydrid Biocompositesmentioning

confidence: 99%

Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications

et al. 2022

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“…Hussein et al successfully fabricated Ag–CS nanofibers and it was shown that the combination of Ag–CS Nps and pH in a single electrospun nanofibrous membrane revealed effectiveness in both antibacterial and fibroblast proliferative capabilities. 39 Cells seeded on pH-containing NFs grew faster and produced bigger colonies than the PVA samples and Ag–CS Nps containing NFs. On the other hand, the number of viable cells on Ag NPs containing nanofibrous mats decreased after 3 and 7 days of incubation.…”

Section: Polymersmentioning

confidence: 96%

A review on biopolymer-derived electrospun nanofibers for biomedical and antiviral applications

2022

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“…PCL is a linear, hydrophobic, aliphatic polyester with high mechanical strength and is biocompatible as well as biodegradable [ 172 , 173 ]. Chemotherapeutics [ 154 , 157 , 159 , 174 , 175 , 176 , 177 , 178 , 179 ], antimicrobials [ 162 , 180 , 181 ], and anti-inflammatory drugs [ 160 , 182 ] have been delivered using PCL.…”

Section: Synthetic Biopolymer Scaffolds For Therapeutic Ev Deliverymentioning

confidence: 99%

“…Chemotherapeutics [ 154 , 157 , 159 , 174 , 175 , 176 , 177 , 178 , 179 ], antimicrobials [ 162 , 180 , 181 ], and anti-inflammatory drugs [ 160 , 182 ] have been delivered using PCL. Furthermore, PCL has been used for the delivery of hypotensive agents [ 183 ], protease inhibitors [ 184 ], anticonvulsants [ 172 ], and sulfonylureas [ 185 ]. In addition to drug delivery, PCL has been used to deliver polyphenols [ 186 ], antiretrovirals, and hormones [ 187 ].…”

Section: Synthetic Biopolymer Scaffolds For Therapeutic Ev Deliverymentioning

confidence: 99%

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

Leung

Shirazi

Cooper

et al. 2022

Cells

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In this review, we will discuss the current status of extracellular vesicle (EV) delivery via biopolymeric scaffolds for therapeutic applications and the challenges associated with the development of these functionalized scaffolds. EVs are cell-derived membranous structures and are involved in many physiological processes. Naïve and engineered EVs have much therapeutic potential, but proper delivery systems are required to prevent non-specific and off-target effects. Targeted and site-specific delivery using polymeric scaffolds can address these limitations. EV delivery with scaffolds has shown improvements in tissue remodeling, wound healing, bone healing, immunomodulation, and vascular performance. Thus, EV delivery via biopolymeric scaffolds is becoming an increasingly popular approach to tissue engineering. Although there are many types of natural and synthetic biopolymers, the overarching goal for many tissue engineers is to utilize biopolymers to restore defects and function as well as support host regeneration. Functionalizing biopolymers by incorporating EVs works toward this goal. Throughout this review, we will characterize extracellular vesicles, examine various biopolymers as a vehicle for EV delivery for therapeutic purposes, potential mechanisms by which EVs exert their effects, EV delivery for tissue repair and immunomodulation, and the challenges associated with the use of EVs in scaffolds.

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Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers

Cited by 74 publications

References 52 publications

Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications

Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications

A review on biopolymer-derived electrospun nanofibers for biomedical and antiviral applications

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

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