Dual-core all-fiber integrated immunosensor for detection of protein antigens

Wysokiński, Karol I.; Budnicki, Dawid; Fidelus, Janusz D.; Szostkiewicz, Lukasz; Ostrowski, L.; Murawski, M.; Staniszewski, Marcin; Staniszewska, Magdalena; Napierała, Marek; Nasiłowski, Tomasz

doi:10.1016/j.bios.2018.05.008

Cited by 13 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Note that these layers include the antigen coating and any antibodies that could have attached to the functionalized PDMS surface. Hence, considering that the tests were performed with the same immunosensors, the thickness difference could be attributed to changes in the PDMS end-cap surface owing to antigen-antibody binding effects, as resported previously for other bio-sensing platforms [9,38].…”

Section: Antigen Immobilization and Immunoassay Resultsmentioning

confidence: 93%

Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids

Cano‐Velázquez¹,

López-Marı́n²,

Hernández‐Cordero³

2020

Biomed. Opt. Express

View full text Add to dashboard Cite

We demonstrate a novel and simple means to fabricate optical fiber immunosensors based on Fabry-Perot (F-P) interferometers using polydimethylsiloxane (PDMS) as support for bioactive lipids. The sensors are fabricated following a straightforward dip-coating method producing PDMS end-capped devices. A biosensing platform is realized by subsequent functionalization of the PDMS cap with a previously characterized bioactive lipid antigen cocktail from Mycobacterium fortuitum, used as a surrogate source of antigens for tuberculosis diagnosis. After functionalization of the PDMS, the F-P sensors were immersed in different antibody-containing sera and the registered changes in their spectral features were associated to the interactions between the active lipids and the serum antibodies. Our results show that the proposed PDMS end-capped F-P immunosensors perform well differentiating antibody-containing sera. Furthermore, they offer attractive attributes such as label-free operation, real-time detection capabilities and they are also reusable. The proposed sensors, therefore, serve as an enabling optical immunosensing technique offering excellent potential for developing novel lipidomic analytical tools.

show abstract

Section: Antigen Immobilization and Immunoassay Resultsmentioning

confidence: 93%

Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids

Cano‐Velázquez¹,

López-Marı́n²,

Hernández‐Cordero³

2020

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…In 2018, Wysokiński et al presented an optical fiber protein sensor to achieve specific detection of specific proteins [79]. The results show that the optical fiber interferometer sensor detects the protein antigens in the solution by coating with specific antibodies.…”

Section: The Principle and Applications Of Biosensors Based On Specialty Fiber Interferometermentioning

confidence: 99%

A review of specialty fiber biosensors based on interferometer configuration

Chen

Zhou

et al. 2021

Journal of Biophotonics

View full text Add to dashboard Cite

Optical fiber biosensors have attracted extensive research attention in fields such as public health research, environmental science, bioengineering, disease diagnosis and drug research. Accurate detection of biomolecules is essential to limit the extent of disease outbreaks and provide valuable guidance for regulatory agencies to take timely measures. Among many optical fiber sensors, optical fiber biosensors based on specialty fibers have the advantages of biocompatibility, small size, high measurement resolution, high stability and immunity to electromagnetic interference. In this paper, four types interferometer biosensors based on specialty fiber, namely Mach‐Zehnder interferometer, Michelson interferometer, Fabry ‐ Perot interferometer and Sagnac interferometer, are reviewed in terms of operating principles, sensing structure and application fields. The fiber types are further divided into micro‐nano optical fiber, thin core fiber, polarization maintaining fiber, polymer fiber, microstructure optical fiber. Furthermore, this paper evaluates the advantages and disadvantages of these interferometer biosensors. Finally, main challenging problems and expectational development direction of specialty fiber interferometer biosensors are summarized. This text clearly shows the huge development potential of optical fiber biosensors in biomedical.

show abstract

“…The fabrication of miniaturized and integrated in-fiber devices of an optical system has driven a lot of research interest [1][2][3][4][5]. Since the birth of photonic crystal fibers (PCFs) in 1995, PCF has been extensively practiced in many fields, such as biosensors [6], passive optical devices [7,8], and medicine [3], owing to its structural flexibility [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…The PWDT property is caused by the surface plasmon polariton (SPP), which is excited at the metal-dielectric interface due to the stimulation of light. Consequently, this phenomenon has already been studied in many potential applications including polarizers [16][17][18][19][20], sensors [4,6,21], and in-fiber devices [2,5,22].…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of copper-filled photonic crystal fiber based polarization filters

et al. 2019

View full text Add to dashboard Cite

This work demonstrates a broadband polarization filter based on copper-filled photonic crystal fiber (CFPCF). The proposed fiber is fabricated using the conventional stack-and-draw method. The polarization filter properties of the proposed CFPCF are investigated numerically by considering the cross-sectional scanning electron microscopy image of the fabricated CFPCF. It is observed that the magnitude of cross talk reached up to −206 dB over 0.8 mm length with a broad bandwidth of 282 nm at a central wavelength of 1790 nm. In addition, the polarization characteristics of the CFPCF including cross talk, central wavelength, and bandwidth can be adjusted by varying the diameter of the copper wire. It is shown that the resonance wavelength of the proposed filter can be tuned over the wide range of wavelengths from 1390 to 1890 nm. We have shown that by adjusting the copper wire diameter to 0.32Λ and 0.48Λ μm (Λ is pitch size), the proposed filter can operate at communication bands of 1310 and 1550 nm, respectively. The results suggest high-potential of the proposed fiber for polarization filtering and other sensing applications.

show abstract

Dual-core all-fiber integrated immunosensor for detection of protein antigens

Cited by 13 publications

References 35 publications

Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids

Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids

A review of specialty fiber biosensors based on interferometer configuration

Design and fabrication of copper-filled photonic crystal fiber based polarization filters

Contact Info

Product

Resources

About