Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice

Horie, Minoru; Tsukano, Hiroaki; Hishida, Ryuichi; Takebayashi, Hirohide; Shibuki, Katsuei

doi:10.1016/j.neures.2013.05.004

Cited by 33 publications

(49 citation statements)

References 25 publications

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“…Anatomical and physiological studies have documented the distinct inputs and unique response properties of the different auditory fields. For example, AAF and A1 receive input from two distinct regions of the thalamus that have independent tonotopic axes: the medial ventral division of the medial geniculate and the lateral ventral division of the medial geniculate (Horie et al, ). AAF neurons in VPA exposed rats have many basic firing property differences: higher thresholds, wider bandwidths, longer latencies, and weaker spike rates to tones.…”

Section: Discussionmentioning

confidence: 99%

Degraded auditory processing in a rat model of autism limits the speech representation in non‐primary auditory cortex

Engineer

Centanni

et al. 2014

Developmental Neurobiology

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Although individuals with autism are known to have significant communication problems, the cellular mechanisms responsible for impaired communication are poorly understood. Valproic acid (VPA) is an anticonvulsant that is a known risk factor for autism in prenatally exposed children. Prenatal VPA exposure in rats causes numerous neural and behavioral abnormalities that mimic autism. We predicted that VPA exposure may lead to auditory processing impairments which may contribute to the deficits in communication observed in individuals with autism. In this study, we document auditory cortex responses in rats prenatally exposed to VPA. We recorded local field potentials and multiunit responses to speech sounds in primary auditory cortex, anterior auditory field, ventral auditory field. and posterior auditory field in VPA exposed and control rats. Prenatal VPA exposure severely degrades the precise spatiotemporal patterns evoked by speech sounds in secondary, but not primary auditory cortex. This result parallels findings in humans and suggests that secondary auditory fields may be more sensitive to environmental disturbances and may provide insight into possible mechanisms related to auditory deficits in individuals with autism.

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Section: Discussionmentioning

confidence: 99%

Degraded auditory processing in a rat model of autism limits the speech representation in non‐primary auditory cortex

Engineer

Centanni

et al. 2014

Developmental Neurobiology

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“…The tonotopic organization of fields A1 or AAF as well as several secondary auditory fields have been identified in the mouse auditory cortex using conventional microelectrode mapping of multiunit spiking in the thalamorecipient layers [26, 45–49] or low-resolution optical imaging of voltage-sensitive dye [50], flavoprotein autofluorescence [51, 52], and intrinsic signals [53]. Tonotopic organization in the middle layers of mouse A1 likely arises from topographically organized feedforward projections from the MGBv [45]; Fig.…”

Section: The Case Of the Mousementioning

confidence: 99%

Local versus global scales of organization in auditory cortex

Kanold

Nelken

Polley

2014

Trends in Neurosciences

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Topographic organization is a hallmark of sensory cortical organization. Topography is robust at spatial scales ranging from hundreds of microns to centimeters, but can dissolve at the level of neighboring neurons or subcellular compartments within a neuron. This dichotomous spatial organization is especially pronounced in the mouse auditory cortex, where an orderly tonotopic map can arise from heterogeneous frequency tuning between local neurons. Here, we address a debate surrounding the robustness of tonotopic organization in the auditory cortex that has persisted in some form for over forty years. Drawing from various cortical areas, cortical layers, recording methodologies, and species, we describe how auditory cortical circuitry can simultaneously support a globally systematic, yet locally heterogeneous representation of this fundamental sound property.

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“…Traditionally, thalamic nuclei like the medial and lateral geniculate have been described as relay stations for auditory and visual information, respectively. For example, the most studied function of the medial geniculate nucleus (MGN) is its role in passing auditory information from the inferior colliculus to the auditory cortex (Budinger et al, 2000; Crippa et al, 2010; Geiser et al, 2012; Horie et al, 2013; Jones, 1985; Llano and Sherman, 2008; Mesulam and Pandya, 1973; Monakow, 1914; Poliak, 1926; Redies et al, 1989; Ryugo and Killackey, 1974; Tunturi, 1946; Walker, 1937). However, there is also evidence the MGN has a far broader role in multisensory processing (Blum et al, 1979; Brinkhus et al, 1979; Carstens and Yokota, 1980; Love and Scott, 1969; Wepsic, 1966).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, existing MGN/S connectivity work uses different methodologies in mice versus humans - mouse MGN/S connections were studied using injection tract tracing(Horie et al, 2013; Llano and Sherman, 2008), while human MGN/S connections to the amygdala and the inferior colliculus used diffusion weighted MRI methods(DTI)(Crippa et al, 2010; Devlin et al, 2006; Javad et al, 2013). Furthermore, given that anatomy and physiology differ in some systems between humans and other species (Carlson, 2012; Manger et al, 2008; Preuss, 2000; Smulders, 2009), verification of homologous MGN/S connectivity across species is an important foundational step for translational research.…”

Section: Introductionmentioning

confidence: 99%

A comparative analysis of mouse and human medial geniculate nucleus connectivity: A DTI and anterograde tracing study

et al. 2015

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Understanding the function and connectivity of thalamic nuclei is critical for understanding normal and pathological brain function. The medial geniculate nucleus (MGN) has been studied mostly in the context of auditory processing and its connection to the auditory cortex. However, there is a growing body of evidence that the MGN and surrounding associated areas (‘MGN/S’) have a diversity of projections including those to the globus pallidus, caudate/putamen, amygdala, hypothalamus, and thalamus. Concomitantly, pathways projecting to the medial geniculate include not only the inferior colliculus but also the auditory cortex, insula, cerebellum, and globus pallidus. Here we expand our understanding of the connectivity of the MGN/S by using comparative diffusion weighted imaging with probabilistic tractography in both human and mouse brains (most previous work was in rats). In doing so, we provide the first report that attempts to match probabilistic tractography results between human and mice. Additionally, we provide anterograde tracing results for the mouse brain, which corroborate the probabilistic tractography findings. Overall, the study provides evidence for the homology of MGN/S patterns of connectivity across species for understanding translational approaches to thalamic connectivity and function. Further, it points to the utility of DTI in both human studies and small animal modeling, and it suggests potential roles of these connections in human cognition, behavior, and disease.

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Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice

Cited by 33 publications

References 25 publications

Degraded auditory processing in a rat model of autism limits the speech representation in non‐primary auditory cortex

Degraded auditory processing in a rat model of autism limits the speech representation in non‐primary auditory cortex

Local versus global scales of organization in auditory cortex

A comparative analysis of mouse and human medial geniculate nucleus connectivity: A DTI and anterograde tracing study

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