Dual-Color-Coded Imaging of Viable Circulating Prostate Carcinoma Cells Reveals Genetic Exchange between Tumor Cells In Vivo, Contributing to Highly Metastatic Phenotypes

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

“…It should also be noted that out studies as well as the studies with SKPs used fluorescent proteins to track the transplanted cells, a technology pioneered in our laboratory. [21][22][23][24][25] Soluble factors secreted from host cells as well as hair follicle stem cells may play a role in the regeneration of spinal cord injury. For example, brain-derived neurotrophic factor (BDNF) and insulin-like growth factor (IGF-1) were shown to be involved in nerve regeneration.…”

Genomic Models of Metastatic Cancer: Functional Analysis of Death-from-Cancer Signature Genes Reveals Aneuploid, Anoikis-Resistant, Metastasis-Enabling Phenotype with Altered Cell Cycle Control and Activated PcG Protein Chromatin Silencing Pathway

“…21,65 It has been suggested that enrichment of primary tumors with NSCs increases likelihood of horizontal genomic transfer between NSCs and tumor cells via cell fusion and/or uptake of apoptotic bodies. 21 Progeny of reprogrammed somatic hybrid cells contain a sub-population of self-renewing cancer stem cells with epigenetic and transcriptional markers of NSCs and high propensity toward metastatic dissemination.…”

“…6,21 Recent experiments employing dual-color fluorescent orthotopic models of human prostate cancer metastasis in nude mice directly support the idea that spontaneous genetic exchange between tumor cells in vivo contributes to genomic instability and creation of highly metastatic cells. 65 One of the most fascinating aspects of this problem is the ability of viruses to facilitate cell fusion and generate transformed human cells by fusion. 66,67 Cell fusion is mediated by viral proteins facilitating the entry of enveloped viruses into the cells.…”

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

“…7,8 Conversely, this modification can be erased by deubiquitylating enzymes (DUBs). Numerous DUBs have been reported to deubiquitylate H2Bub1, 9 most notably USP22, 10 which is often upregulated in cancer and is part of a cancer gene signature associated with stem cell-like features and bad prognosis, 11 and USP44, 12 reported to contribute to breast cancer aggressiveness. 13 Modulation of H2Bub1 levels can upregulate the expression of specific gene sets in a cell type-specific manner, while repressing other gene sets.…”