Dual channel selective fluorescent detection of Al³⁺ and PPi in mixed aqueous media: DFT studies and cell imaging applications

Abstract

A new, easily synthesizable chemosensor, DFC-EN-p-Ph-NO2, acts as a dual channel (colori- and fluorimetric) sensor for Al3+ and PPi.

A Spectral Probe for Detection of Aluminum (III) Ions Using Surface Functionalized Gold Nanoparticles

“…The spectral response induced by intraparticle plasmon-plasmon coupling can be examined by changes in SPR band, in addition to this it can be a basis for surface-enhanced Raman scattering of organic molecules capped on nanoparticles surfaces [ 56 , 57 ]. Al 3+ spiked real samples was used to observe spectral shifts in a reasonable range (50 ppb) as compared with literature values summarized in Table 1 and reported for Al 3+ detection using different approaches [ 48 , 58 , 59 , 60 ].…”

Gold Triangular Nanoplates Based Single-Particle Dark-Field Microscopy Assay of Pyrophosphate

“…Pyrophosphate (PPi), a dimeric form of inorganic phosphate (Pi), is an important biological anion that plays significant roles in various fundamental physiological processes, such as cellular metabolism, ATP hydrolysis, and RNA and DNA polymerizations. , It is well-known that the prevalence of pyrophosphate arthropathy including chondrocalcinosis or calcium pyrophosphate dihydrate (CPPD) crystal deposition disease increases with aging owing to the significant increase of PPi concentration in synovial fluid . In addition, the levels of PPi in cells have become a potential indicator for early diagnosis of cancer, , and it is also used as an additive in toothpaste, detergents, baking powder, and food. , Therefore, the detection of PPi with high sensitivity and high selectivity is still urgently needed. Until now, different approaches including fluorescence and electrochemistry methods have been the commonly used methods. − However, these methods are laborious, operationally cumbersome, and insufficient in real-time measurement.…”

“…29 In addition, the levels of PPi in cells have become a potential indicator for early diagnosis of cancer, 30,31 and it is also used as an additive in toothpaste, detergents, baking powder, and food. 32,33 Therefore, the detection of PPi with high sensitivity and high selectivity is still urgently needed. Until now, different approaches including fluorescence and electrochemistry methods have been the commonly used methods.…”