Dual Catalytic Strategy for Forging sp²–sp³and sp³–sp³Architectures via β-Scission of Aliphatic Alcohol Derivatives

Abstract

A dual platform for forging sp2 –sp3 and sp3 –sp3 carbon bonds via catalytic β-scission of aliphatic alcohol derivatives with both aryl and alkyl halides is disclosed. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization.

Photoinduced Nickel-Catalyzed Deaminative Cross-Electrophile Coupling for C(sp2)–C(sp3) and C(sp3)–C(sp3) Bond Formation

“…In particular, reductive cross-electrophile coupling has witnessed rapid development over the last two decades . These transformations obviate the need to presynthesize organometallic reagents, allowing the direct union of two relatively more stable electrophilic organohalides, pseudohalides, or redox-active substrates to deliver the product.…”

Organic thermally activated delayed fluorescence (TADF) compounds used in photocatalysis

“…94b). 258 The putative mechanism is shown in Fig. 95 and reflects the general mechanism shown in Fig.…”

Photoredox Dual Catalysis: A Fertile Playground for the Discovery of New Reactivities

“…Following this report, the same group disclosed the compatibility of this dual catalytic platform with vinyl halides [43] and alkyl halides [44] . This cross‐coupling manifold is also prone to the employment of other alkyl radical sources such as alkylbis(catecholato)silicates, [45] 4‐alkyl‐1,4‐dihydropyridines [46] and aliphatic alcohols [47] …”