Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development.

Higashijima, Shin‐ichi; Kojima, Takao; Michiue, Tatsuo; Ishimaru, Satoshi; Emori, Yasufumi; Saigo, Kaoru

doi:10.1101/gad.6.1.50

Cited by 225 publications

(180 citation statements)

References 27 publications

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“…BarH1 and BarH2 are two closely related homeo box genes that form a small complex at the Bar locus on the X chromosome of Drosophila (Higashijima et al 1992). Their overexpression at the late third instar causes reduced eye morphology similar to that noted in the B mutation (Kojima et al 1991;unpubl.…”

Section: ~Corresponding Authormentioning

confidence: 83%

Subtype determination of Drosophila embryonic external sensory organs by redundant homeo box genes BarH1 and BarH2.

Higashijima

Michiue²,

Emori³

et al. 1992

Genes Dev.

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102

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BarH1 and BarH2 are two closely related homeo box genes that form a small complex at the Bar locus on the X chromosome of Drosophila. By immunostaining, we showed that BarHl and BatH2 proteins are coexpressed in cells belonging to the central and peripheral nervous systems in embryos. In external sensory (es) organs, their expression was particularly apparent in thecogens (glial cells) and neurons at late development. Although deletion of BatH2 caused no appreciable morphological change in es organs, the simultaneous deletion of BatH1 and BatH2 led to a homeotic change in these organs with consequent conversion from campaniform-like sensilla to trichoid sensilla. In contrast, the overexpression of either BatH1 or BarH2 resulted in opposite morphological change. It would thus follow that BarH1 and BarH2 are a pair of redundant homeo box genes required for the subtype specification of es organs.

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Section: ~Corresponding Authormentioning

confidence: 83%

Subtype determination of Drosophila embryonic external sensory organs by redundant homeo box genes BarH1 and BarH2.

Higashijima

Michiue²,

Emori³

et al. 1992

Genes Dev.

Self Cite

102

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“…6A), suggesting that R1/R6 cells have a strong, although not absolute, requirement for Lz. A gene product required specifically in R1 l R 6 cells to specify their fate is the homeo domain protein Bar (Higashijima et al 1992). To establish whether Lz was implicated in transcriptionally regulating this protein, lz" discs were stained with an antibody against Bar.…”

Section: Lz Positively Regulates Barmentioning

confidence: 99%

“…To carry out their differentiation program properly, in addition to Svp, photoreceptors R1 /R6 require the product of the gene Bar (Higashijima et al 1992)) a homeo domain protein whose expression is restricted exclusively to RllR6. Thus, the coordinate control of the expression of Svp and Bar is important in the specification of equivalence groups of cells.…”

mentioning

confidence: 99%

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

Daga¹,

et al. 1996

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The lozenge (lz) gene encodes a transcription factor involved in prepatterning photoreceptor precursors in the developing Drosophila eye. The central region of the predicted Lz protein product is homologous to AML1, a transcription factor associated with human leukemias, and to the Drosophila protein Runt. We show here that Lz plays a crucial role in governing the fate of two groups of cells that are born in a single round of mitosis in the larval eye disc. Lz helps define a subset of these cells as an equipotential group that is competent to respond to the Sevenless developmental signal. This is achieved by negative regulation of seven-up, a member of the steroid hormone receptor superfamily in these cells. In contrast, in a second group of cells, the Lz protein confers proper photoreceptor identity by positively regulating the homeo box gene Bar. Additionally, our genetic analysis suggests that Lz interacts with the Ras pathway to determine photoreceptor cell fate. This study suggests that the strategies involved in cell fate determination in the Drosophila eye are remarkably similar to those utilized during vertebrate hematopoietic development and require the coordinate action of growth factor and AML1-like pathways.

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“…When both Bar genes are deleted in the Drosophila notum, papillae are transformed into hairs, whereas the ubiquitous expression of one of them turns hairs into papillae. Analogously, overexpression of BarH1 in the eye region transforms cones into R1/R6 photoreceptors, whereas deletion of BarH1/BarH2 function in the eye transforms R1/R6 photoreceptors into cone cells (Higashijima et al, 1992a;Higashijima et al, 1992b;Sato et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Vertebrate Bar homeobox genes are related to Drosophila BarH1 and BarH2 genes. Mutations in these genes result in the suppression of the anterior part of the eye (Higashijima et al, 1992a;Kojima et al, 1991). Both genes act in a redundant way, and are necessary for the correct development of the external sensory organs and the eye (Higashijima et al, 1992b).…”

Section: Introductionmentioning

confidence: 99%

The homeobox geneXbh1cooperates with proneural genes to specify ganglion cell fate within theXenopusneural retina

et al. 2004

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Recent studies on vertebrate eye development have focused on the molecular mechanisms of specification of different retinal cell types during development. Only a limited number of genes involved in this process has been identified. In Drosophila, BarH genes are necessary for the correct specification of R1/R6 eye photoreceptors. Vertebrate Bar homologues have been identified and are expressed in vertebrate retinal ganglion cells during differentiation; however, their retinal function has not yet been addressed. In this study, we report on the role of the Xenopus Bar homologue Xbh1 in retinal ganglion cell development and its interaction with the proneural genes Xath5 and Xath3, whose ability to promote ganglion cell fate has been demonstrated. We show that XHB1 plays a crucial role in retinal cell determination, acting as a switch towards ganglion cell fate. Detailed expression analysis, animal cap assays and in vivo lipofection assays, indicate that Xbh1 acts as a late transcriptional repressor downstream of the atonal genes Xath3 and Xath5. However, the action of Xbh1 on ganglion cell development is different and more specific than that of the Xath genes, and accounts for only a part of their activities during retinogenesis.

show abstract

Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development.

Cited by 225 publications

References 27 publications

Subtype determination of Drosophila embryonic external sensory organs by redundant homeo box genes BarH1 and BarH2.

Subtype determination of Drosophila embryonic external sensory organs by redundant homeo box genes BarH1 and BarH2.

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

The homeobox geneXbh1cooperates with proneural genes to specify ganglion cell fate within theXenopusneural retina

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