Dual activity maps in primate visual cortex produced by different temporal patterns of
            <i>zif268</i>
            mRNA and protein expression

Chaudhuri, Avi; Nissanov, Jonathan; Larocque, Sylvie; Rioux, Lise

doi:10.1073/pnas.94.6.2671

Cited by 57 publications

(21 citation statements)

References 19 publications

(17 reference statements)

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“…Taken together, our findings indicate that egr1 is a useful marker for mapping physiological activity in the brain. Indeed, MD by enucleation, TTX injection, or eyelid suture dramatically reduces egr1 levels, revealing vertically oriented columns in the monkey visual cortex reflecting alternating right and left eye input (Chaudhuri and Cynader, 1993;Chaudhuri et al, 1995Chaudhuri et al, , 1997Kaczmarek et al, 1999). Similar results have been obtained by studying retinal lesions in adult cats (Arckens et al, 2000) and enucleation in young rats .…”

Section: Development and Activity-dependent Regulation Of Egr1 In Vissupporting

confidence: 70%

Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268

et al. 2001

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Neuronal activity elicits a rapid increase in the expression of several immediate early genes (IEGs). To clarify a role for IEG response in activity-dependent development, we examined the contribution of the egr1/zif268 gene during visual cortical processing and plasticity in mice. We first analyzed the expression of egr1 mRNA in wild-type (WT) mice using Northern blot hybridization. In the visual cortex, expression of egr1 mRNA increased dramatically after eye opening, systemic injection of kainate, or 30 min of photostimulation after a brief (5 d) period of dark adaptation. Thus, the expression of egr1 is regulated by synaptic activity in the mouse visual cortex, as it is in other species (e.g., monkeys, cats, and rats). To evaluate whether this transcription factor is directly involved in activity-dependent plasticity, mice lacking Egr1 were deprived of the use of one eye during the developmental critical period [postnatal day 24 (P24)-P34]. Extracellular in vivo single-unit recordings from the binocular zone of the visual cortex revealed that visual responses developed normally in egr1 knock-out (KO) mice. Moreover, a similarly significant shift of responsiveness in favor of the open eye was produced in both KO and WT mice by either brief (4 d) or long-term (>2 weeks) occlusion of one eye. There was no apparent compensation among egr2, egr3, or c-fos mRNA and protein expression in the visual cortex of egr1 KO mice. Taken together, these results indicate that egr1 is a useful marker of sensory input in mice but is not intrinsically necessary for the experience-dependent plasticity of the visual cortex. Our findings underscore a mechanistic distinction between sensory plasticity and long-lasting forms of synaptic potentiation in the hippocampus, for which egr1/zif268 was recently found to be essential.

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Section: Development and Activity-dependent Regulation Of Egr1 In Vissupporting

confidence: 70%

Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268

et al. 2001

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“…Neurones that are triggered by both stimuli display both markers. This approach has been used in several experiments, including studies on the visual system (79, 80), to differentiate cellular target of different drugs (81) and stress‐related targets (Fig. 2; KJ.…”

Section: Advanced Activity Studiesmentioning

confidence: 99%

Measurement of Immediate‐Early Gene Activation‐ c‐fos and Beyond

Kovács

2008

J Neuroendocrinology

413

295

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Immediate‐early genes (IEG) are powerful tools for identifying activated neurosecretory neurones and extended circuits that affect neuroendocrine functions. The generally acknowledged scenario is when cells became activated, IEGs expressed and IEG‐encoded transcription factors affect target gene expression. However, there are several examples in which: (i) neuronal activation occurs without induction of IEGs; (ii) IEG induction is not related to challenge‐induced neuropeptide expression; and (iii) markers of neuronal activation are not expressed in chronically activated neurones. In spite of these limitations, the use of c‐Fos and other regulatory‐ or effector transcription factors as markers of neuronal activation will continue to be an extremely powerful technique. Recently‐developed models, including transgenic mice expressing different marker genes under the regulation of IEG promoters, will help to monitor neuronal activity in vivo or ex vivo and to reveal connection between activated neurones. Furthermore, combinations between novel imaging techniques, such as magnetic resonance and IEG‐based mapping strategies, will open new means with which to study functional activity in the neurosecretory systems.

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“…In addition, we used immunohistochemistry to evaluate the product of the immediate early gene, Egr-1, in control and 6-hydroxydopamine (6-OHDA)-lesioned rats to determine the regulation of PPN motor connections in the Parkinsonian state (Beckmann and Wilce 1997; Chaudhuri et al 1997; O’Donovan et al 1999). …”

Section: Introductionmentioning

confidence: 99%

Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism

et al. 2013

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The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region of the PPN is interconnected with motor regions of both the basal ganglia and brainstem/medulla. The co-distribution of ascending and descending motor outputs raises the question as to whether the PPN provides a coordinated or differential modulation of its targets in the basal ganglia and the medulla. To address this, we retrogradely labeled neurons in the two main PPN pathways involved in motor control and determined whether they project to one or both structures, their neurochemical phenotype, and their activity in normal and dopamine depleted rats, as indicated by Egr-1 expression. We show that ascending and descending motor pathways from the PPN arise largely from separate neurons that intermingle in the same region of the PPN, but have a distinct neurochemical composition and are differentially regulated in the Parkinsonian state. Thus, neurons projecting to the subthalamic nucleus consist of cholinergic, calbindin- and calretinin-expressing neurons, and Egr-1 is upregulated following a 6-hydroxydopamine lesion. In contrast, a larger proportion of neurons projecting to the gigantocellular nucleus are cholinergic, none express calbindin and the expression of Egr-1 is not changed by the dopamine lesion. Our results suggest that ascending and descending motor connections of the PPN are largely mediated by different sets of neurons and there are cell type-specific changes in Parkinsonian rats.

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Dual activity maps in primate visual cortex produced by different temporal patterns of zif268 mRNA and protein expression

Cited by 57 publications

References 19 publications

Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268

Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268

Measurement of Immediate‐Early Gene Activation‐ c‐fos and Beyond

Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism

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