Dual actions of gallic acid and andrographolide trigger AdipoR1 to stimulate insulin secretion in a streptozotocin-induced diabetes rat model

Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/streptozotocin-induced type 2 diabetic mice

“… 37 The combination of gallic acid and andrographolide stimulates insulin secretions in STZ-induced diabetic rats. 38 Osthole showed hypoglycemic effects in diabetic db/db mice via dual PPARα/PPARγ activations. 39 Similarly, isoquercitrin inhibited DPP-IV in mice with type 2 diabetes, enhancing and maintaining GLP-1 and insulin activities.…”