Dual-action hygienic coatings: Benefits of hydrophobicity and silver ion release for protection of environmental and clinical surfaces

Stobie, Niall; Duffy, Brendan; Colreavy, John; McHale, Patrick; Hinder, Steven J.; McCormack, Declan E.

doi:10.1016/j.jcis.2010.02.009

Cited by 33 publications

(28 citation statements)

References 38 publications

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“…[49][50][51] During the whole experiment, the soluble silver concentration remained in the ppb range. Silver concentrations as low as 0.1 ppb have been reported as having a bactericidal effect in water.…”

Section: Release Of Silver Ions From the Coatingmentioning

confidence: 96%

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

et al. 2014

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Environmental surfaces are increasingly recognized as important sources of transmission of hospital-acquired infections. The use of antibacterial surface coatings may constitute an effective solution to reduce the spread of contamination in healthcare settings, provided that they exhibit sufficient stability and a long-term antibacterial effect. In this study, silver-incorporated diamondlike carbon films (Ag-DLC) were prepared in a continuous, single-step plasma process using a hybrid, inductively coupled plasma reactor combined with a very-low-frequency sputtering setup. The average Ag concentration in the films, ranging from 0 to 2.4 at. %, was controlled by varying the sputtering bias on the silver target. The authors found that the activity of Escherichia coli was reduced by 2.5 orders of magnitude, compared with the control surface, after a 4-h contact with a 2.4 at. % Ag-DLC coating. The coatings displayed slow release kinetics, with a total silver ion release in the sub-ppb range after 4 h in solution, as measured by graphite furnace-atomic absorption spectroscopy. This was confirmed by Kirby–Bauer diffusion tests, which showed limited diffusion of biocidal silver with a localized antibacterial effect. As a slow and continuous release is mandatory to ensure a lasting antibacterial effect, the newly developed Ag-DLC coatings appears as promising materials for environmental hospital surfaces.

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Section: Release Of Silver Ions From the Coatingmentioning

confidence: 96%

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

et al. 2014

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“…336 This was also demonstrated with silverdoped perfluoropolyether-urethane siloxane thin films deposited on a glass substrate. 337 The hydrophobic sites of this coating are proposed to protect the action of silver ions. In fact, the hydrophobic sites seem to inhibit the attachment of ionic species that might reduce the available silver ions located on the surface or form silver salt deposits (see Figure 25, section 5.5), which would considerably reduce the biocidal action of silver, as shown in section 3.1.…”

Section: Hybrid Silver Materials − Synergistic Effectsmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

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Introduction 4708 2. Peptides and Silver 4709 2.1. Silver Binding to Amino Acids and Peptides 4709 2.1.1. Silver Binding to Amino Acids − Theory 4709 2.1.2. Silver Binding to Amino Acids − Experiment 4711 2.1.3. Silver Binding to Peptides 4711 2.2. Natural Peptides Involved in Metal Detoxification 4714 2.3. Peptides for the Formation of Silver Nanostructures 4716 2.3.1. Biomineralization of Silver by Means of Peptides 4716 2.3.2. Peptides as Structure-Determining Scaffolds in the Synthesis of Silver Nanostructures 4721 3. Bacteria and Silver 4722 3.1. Antimicrobial Properties of Silver-Containing Compounds 4722 3.1.1. Interactions with the Bacterial Cell Wall 4722 3.1.2. Interactions with DNA, Enzymes, and Membrane Proteins 4724 3.1.3. Generation of Reactive Oxygen Species 4725 3.2. Bacterial Resistance Mechanisms against Ag(I) 4726 3.2.1. Accumulation and Storage-Based Mechanism 4726 3.2.2. Efflux Pump-Based Mechanism 4727 3.3. Synthesis of Silver Nanoparticles by Means of Bacteria 4728 4. Silver-Based Biomaterials in the Medical Field 4730 4.1. Types of Silver-Containing Biomaterials 4731 4.1.1. Metallic Silver Coatings and Silver's Antimicrobial Efficiency 4731 4.1.2. Silver-Containing Nanocomposites 4732 4.1.3. Silver-Containing Polymers 4732 4.1.4. Surface Modification with Ionic Silver Compounds 4734 4.1.5. Hybrid Silver Materials − Synergistic Effects 4734 4.2. Deposition Processes 4735 4.3. Mechanical Properties 4736 5. Biocompatibility of Silver 4737 5.1. General Routes of Silver Exposure 4737 5.2. Exposure to Silver-Containing Medical Products 4737 5.2.1. Dermal Contact: Burn Wound Dressings 4737 5.2.2. Bone Contact: Orthopedic and Dental Implants and Bone-Filling Products 4738 5.2.3. Blood Contact: Implants Introduced into the Vascular System 4739 5.3. Effects of Silver Exposure on Tissues and Organs 4739 5.3.1. Acute and Chronic Toxicity of Silver 4740 5.3.2. Tissue and Organ Damages 4740 5.3.3. Cellular Uptake of Silver 4741 5.4. Toxic Effects of Silver Nanoparticles 4741 5.5. Silver Detoxification 4742 5.5.1. Sequestration of Silver Ions 4742 5.5.2. Silver Ion Transport by ATPase P-type Efflux Pumps 4743 6. Conflicting Evidence 4744 7. Conclusions 4744 Author Information 4744 Corresponding Author 4744 Notes 4744 Biographies 4745 Acknowledgments 4746 References 4746

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“…They therefore rely on additional diffusible antimicrobials, such as rifampin, to which microbes may also become resistant. Silver has been incorporated into various products, including coatings and textiles (221)(222)(223). Some coatings demonstrate good antibacterial activity against planktonic Staphylococcus epidermidis and A. baumannii and have been used to inhibit environmental contamination as well as colonization of implanted medical catheters and other devices (223).…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Controlling Hospital-Acquired Infection: Focus on the Role of the Environment and New Technologies for Decontamination

2014

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SUMMARY There is increasing interest in the role of cleaning for managing hospital-acquired infections (HAI). Pathogens such as vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), multiresistant Gram-negative bacilli, norovirus, and Clostridium difficile persist in the health care environment for days. Both detergent- and disinfectant-based cleaning can help control these pathogens, although difficulties with measuring cleanliness have compromised the quality of published evidence. Traditional cleaning methods are notoriously inefficient for decontamination, and new approaches have been proposed, including disinfectants, steam, automated dispersal systems, and antimicrobial surfaces. These methods are difficult to evaluate for cost-effectiveness because environmental data are not usually modeled against patient outcome. Recent studies have reported the value of physically removing soil using detergent, compared with more expensive (and toxic) disinfectants. Simple cleaning methods should be evaluated against nonmanual disinfection using standardized sampling and surveillance. Given worldwide concern over escalating antimicrobial resistance, it is clear that more studies on health care decontamination are required. Cleaning schedules should be adapted to reflect clinical risk, location, type of site, and hand touch frequency and should be evaluated for cost versus benefit for both routine and outbreak situations. Forthcoming evidence on the role of antimicrobial surfaces could supplement infection prevention strategies for health care environments, including those targeting multidrug-resistant pathogens.

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Dual-action hygienic coatings: Benefits of hydrophobicity and silver ion release for protection of environmental and clinical surfaces

Cited by 33 publications

References 38 publications

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Controlling Hospital-Acquired Infection: Focus on the Role of the Environment and New Technologies for Decontamination

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