DTI voxelwise analysis did not differentiate older depressed patients from older subjects without depression

Bezerra, Diana M.; Pereira, F.; Cendes, Fernando; Jackowski, Marcel P.; Nakano, Eduardo Yoshio; Moscoso, Marco Antônio; Ribeiz, Salma Rose Imanari; Ávila, Renata; Castro, Cláudio Campi de; Bottino, Cássio Machado de Campos

doi:10.1016/j.jpsychires.2012.09.001

Cited by 18 publications

(12 citation statements)

References 44 publications

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“…More recent studies confirm this general pattern in individuals with, and those at risk for, depression (132–146), although there are some exceptions (147). …”

Section: Functional and Gray Matter Structural Abnormalities In Implimentioning

confidence: 84%

Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches

Phillips¹,

Chase²,

Sheline³

et al. 2015

AJP

208

164

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Objective Despite significant advances in neuroscience and treatment development, no widely accepted biomarkers are available to inform diagnostics or identify preferred treatments for individuals with major depressive disorder. Method In this critical review, the authors examine the extent to which multimodal neuroimaging techniques can identify biomarkers reflecting key pathophysiologic processes in depression and whether such biomarkers may act as predictors, moderators, and mediators of treatment response that might facilitate development of personalized treatments based on a better understanding of these processes. Results The authors first highlight the most consistent findings from neuroimaging studies using different techniques in depression, including structural and functional abnormalities in two parallel neural circuits: serotonergically modulated implicit emotion regulation circuitry, centered on the amygdala and different regions in the medial prefrontal cortex; and dopaminergically modulated reward neural circuitry, centered on the ventral striatum and medial prefrontal cortex. They then describe key findings from the relatively small number of studies indicating that specific measures of regional function and, to a lesser extent, structure in these neural circuits predict treatment response in depression. Conclusions Limitations of existing studies include small sample sizes, use of only one neuroimaging modality, and a focus on identifying predictors rather than moderators and mediators of differential treatment response. By addressing these limitations and, most importantly, capitalizing on the benefits of multimodal neuroimaging, future studies can yield moderators and mediators of treatment response in depression to facilitate significant improvements in shorter- and longer-term clinical and functional outcomes.

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“…More recent studies confirm this general pattern in individuals with, and those at risk for, depression (132–146), although there are some exceptions (147). …”

Section: Functional and Gray Matter Structural Abnormalities In Implimentioning

confidence: 84%

Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches

Phillips¹,

Chase²,

Sheline³

et al. 2015

AJP

208

164

View full text Add to dashboard Cite

show abstract

“…Nine studies used TBSS analyses of white matter, of which eight compared individuals with LLD to an HC group and one across four groups (LLD, HC, aMCI, LLD+aMCI). Two studies found no significant difference in FA or MD value (Bezerra et al, 2012;Harada et al, 2016); and three reported lower FA only at uncorrected threshold (Colloby et al, 2011;Sexton et al, 2012a;Tadayonnejad et al, 2014). Four studies reported loss of white matter integrity at corrected threshold in individuals with LLD vs. the HC group.…”

Section: Dwi Studies Using Tbssmentioning

confidence: 92%

Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review

et al. 2020

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Depression is a risk factor for developing Alzheimer's disease and Related Dementia (ADRD). We conducted a systematic review between 2008 and October 2018, to evaluate the evidence for a conceptual mechanistic model linking depression and ADRD, focusing on frontal-executive and corticolimbic circuits. We focused on two neuroimaging modalities: diffusion-weighted imaging measuring white matter tract disruptions and resting-state functional MRI measuring alterations in network dynamics in late-life depression (LLD), mild cognitive impairment (MCI), and LLD+MCI vs. healthy control (HC) individuals. Our data synthesis revealed that in some but not all studies, impairment of both frontal-executive and corticolimbic circuits, as well as impairment of global brain topology was present in LLD, MCI, and LLD+MCI vs. HC groups. Further, posterior midline regions (posterior cingulate cortex and precuneus) appeared to have the most structural and functional alterations in all patient groups. Future cohort and longitudinal studies are required to address the heterogeneity of findings, and to clarify which subgroups of people with LLD are at highest risk for developing MCI and ADRD.

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“…Moreover, Bezerra et al [101] reported no significant differences among FA or mean diffusivity values between depressed and non-depressed elderly individuals with or without mild/moderate MDD. Abe et al [102] also suggested no significant difference between 21 right-handed patients and 42 age-and gender-matched controls for FA and whole WM volume.…”

Section: The Role Of Microstructural Wm Brain Abnormalities As Assessmentioning

confidence: 97%

Microstructural brain abnormalities, affective temperaments, and suicidal behavior in patients with major depression

Serafini

Amore

Rihmer

2015

Neuroimmunol Neuroinflammation

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According to magnetic resonance imaging (MRI) studies, brain white matter (WM) abnormalities have been suggested to play a critical role in the pathogenesis of major depressive disorder (MDD) and related suicidal behavior. However, MRI findings may be limited by low spatial resolution; therefore, an important contribution to the understanding of the role and significance of WM alterations derived by the development of the most recent magnetic resonance techniques, such as diffusion tensor imaging (DTI). Several DTI studies reported an association between altered WM integrity and MDD/suicidal behavior. Microstructural WM abnormalities may be located in neural circuits critically implicated in emotional processes and mood regulation resulting in enhanced vulnerability to psychiatric morbidity. WM abnormalities detected using DTI may contribute to functional deficits and help to clarify the pathophysiological mechanisms underlying MDD as well as suicidal behavior. By a clinical point of view, research also suggested that affective temperaments may play a relevant role in the psychopathological characteristics of mood disorders, clinical trajectory of episodes and polarity, long-term outcome and suicidality. Unfortunately, only few studies investigated the association between affective temperaments and WM abnormalities and discussed their possible implications in patients with MDD and suicidal behavior. Using a comprehensive search of Medline database, the aim of the present study was to critically review the current literature on the association between WM alterations as assessed by MRI and DTI techniques, affective temperaments, MDD and suicidal behavior.

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DTI voxelwise analysis did not differentiate older depressed patients from older subjects without depression

Cited by 18 publications

References 44 publications

Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches

Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches

Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review

Microstructural brain abnormalities, affective temperaments, and suicidal behavior in patients with major depression

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