dsRNA as broad-spectrum antiviral therapeutics

Xu, Cong

doi:10.1016/j.omtn.2022.09.023

Cited by 1 publication

(13 citation statements)

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“…Our study shows a significant reduction in mean posttonsillectomy pain in patients irrigated with cold water compared to patients not irrigated with cold water. Our findings are consistent with previous studies 7,8 …”

Section: Discussionsupporting

confidence: 94%

“…7 In another study, however, there were no significant differences seen in pain scores on Day 1. 8 We also observed a mean reduction in pain scores in the intervention group on Days 3, 5, and 7 and our results are consistent with findings from other studies. 1,7,8 Our study results also show a significant reduction in pain in the intervention group versus the control group among patients who had undergone tonsillectomy for recurrent tonsillitis.…”

Section: Sylvester Et Al Who Observed a Reduced Pain Score In Childre...supporting

confidence: 92%

“…Our findings are consistent with previous studies. 7,8 Hypothetically, heat generated from a monopolar cautery would cause dissipation into the surrounding tissue, causing inflammation and irritation of nociceptors. Immediate cooling of the tonsillar fossa would therefore reduce this heat dissipation and reduce thermal damage to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In one study, tonsillectomies were performed concomitantly with uvulopalatoplasties, and due to a small sample size in either group and lack of a subgroup analysis, the external validity of the study was low. 1 In another study, isotonic fluid at room temperature was used to irrigate one tonsil while the other tonsil was left untreated and due to the small sample size and lack of reporting the exact amount of fluid used and the time taken to irrigate, 8 Our study had several limitations. First, our study was a quasiexperimental trial that lacked randomization.…”

Section: Sylvester Et Al Who Observed a Reduced Pain Score In Childre...mentioning

confidence: 95%

“…Tonsillar fossa is richly supplied by nociceptors and postoperative pain may persist for more than a week, thereby limiting daily activities 7 . Various methods have been shown to reduce post‐tonsillectomy pain and immediate cooling of the burnt area on a body surface is one such method, 1,8,9 as was done by Galen and Rhazes back in the 2nd century AD 10,11 . Immediate cooling helps dissipate heat and reduces tissue damage and inflammation, thereby reducing postoperative pain 1,11 …”

Section: Introductionmentioning

confidence: 99%

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Change in mean postoperative pain in patients undergoing tonsillectomy with cold water versus usual practice: A pragmatic trial

Iftikhar

Zahid

Zubair

et al. 2023

World j. otorhinolaryngol.-head neck surg.

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IntroductionTonsillectomy is one of the most common procedures performed in otolaryngology. There are various methods to perform tonsillectomies (cold and hot). Thermal damage and inflammation of the surrounding tissue using monopolar cautery is said to point to increased pain whereas immediate cooling of the burnt area is thought to reduce pain owing to heat dissipation. Our objective was to determine the difference in mean post‐tonsillectomy pain scores among patients irrigated with cold water (4°C) and in patients not irrigated with cold water.Material and MethodsA quasi‐experimental trial was conducted from January 2016 to December 2017 at a tertiary care hospital. All tonsillectomies were carried out with monopolar cautery at a power of 20 W. Patients either received cold water irrigation post tonsillectomy of the tonsillar bed (intervention arm) or no irrigation (control arm). The pain score was measured on Days 0, 1, 3, 5, and 7. Pain scores were charted on a visual analog scale on the respective days.ResultsSeventy‐eight patients were included in the study. The mean age of our patients was 10.26 (4.24) years old in the intervention arm, and 11.95 (4.19) years old in the control arm. It was observed that the pain was significantly lower in patients with cold water irrigation of the tonsillar fossa on Days 1, 3, 5, and 7 (p = 0.001). There were no readmissions postprocedure and none of our patients developed any complications postsurgery.ConclusionsIn this trial, we report a reduced pain score at all days of observation in the intervention group. Irrigation of the tonsillar fossa is a safe, cost‐effective, and less technically demanding technique that could be employed to reduce postoperative pain. Further studies with randomization, blinding and a larger sample size could further improve on our results.

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Section: Discussionsupporting

confidence: 94%