DSM-V Changes for Autism Spectrum Disorder (ASD): Implications for Diagnosis, Management, and Care Coordination for Children With ASDs

Lobar, Sandra L.

doi:10.1016/j.pedhc.2015.09.005

Cited by 42 publications

(31 citation statements)

References 23 publications

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“…It is possible that this phenotype is recapitulated in this Magel2 knockout mouse model, with no deficits of social interaction at baseline, yet lack of increased social interest following the introduction of a novel partner. Diagnostic criteria for ASD include aberrancies or deficits in the maintenance of social interactions (Fakhoury 2015;Lobar 2015). While increased interaction with partner mice may seem to speak against autism-like phenotypes, altered and increased sociability is observed in various mouse models of autism, and may reflect a risk-taking, impulsive behavior (Chao et al 2010;Feyder et al 2010;Schaevitz et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty

Fountain

Tao

Yin

et al. 2017

Genes Brain and Behavior

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MAGEL2 is one of five protein-coding, maternally imprinted, paternally expressed genes in the Prader-Willi syndrome-critical domain on chromosome 15q11-q13. Truncating pathogenic variants of MAGEL2 cause Schaaf-Yang syndrome (OMIM #615547), a neurodevelopmental disorder related to Prader-Willi syndrome. Affected individuals manifest a spectrum of neurocognitive and behavioral phenotypes, including intellectual disability and autism spectrum disorder (ASD). Magel2 knockout mice carrying a maternally inherited, imprinted wildtype allele and a paternally inherited Magel2-lacZ knock-in allele, which abolishes endogenous Magel2 gene function, exhibit several features reminiscent of the human Prader-Willi phenotypes, including neonatal growth retardation, excessive weight gain after weaning, and increased adiposity in adulthood. They were shown to have altered circadian rhythm, reduced motor activity, and reduced fertility. An extensive assessment for autism-like behaviors in this mouse model was warranted, due to the high prevalence of ASD in human patients. The behavior of Magel2 knockout mice and their wildtype littermates were assayed via open field, elevated plus maze, tube, three-chamber, and partition tests. Our studies confirm decreased horizontal activity of male and female mice and increased vertical activity of females, in the open field. Both sexes spent more time in the open arm of the elevated plus maze, suggestive of reductions in anxiety. Both sexes displayed a lack of preference for social novelty, via a lack of discrimination between known and novel partners in the partition test. The in-depth investigation of behavioral profiles caused by Magel2 loss-of-function helps to elucidate the etiology of behavioral phenotypes both for Schaaf-Yang syndrome and Prader-Willi syndrome in general.

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Section: Discussionmentioning

confidence: 99%

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty

Fountain

Tao

Yin

et al. 2017

Genes Brain and Behavior

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“…The dimensional approach is assumed to embrace the heterogeneity that characterizes the condition and thus guide the treatment and adaptation of the environment more appropriately (40)(41)(42). However, some studies have shown that the rates of children diagnosed with ASD are lower when using the DSM-5 rather than the DSM-IV, and that a lack of understanding of the dimensional construct might lead to poorer services for people with ASD (43)(44)(45). Clearly, it is too early to conclude whether the change will represent an improvement or reduce the quality of life for people with ASD, especially regarding the ICD-11 that has recently been released but not implemented.…”

Section: Autism Spectrum Disorder and Diagnostic Criteriamentioning

confidence: 99%

School refusal behaviour: Are children and adolescents with autism spectrum disorder at a higher risk?

Munkhaugen

Gjevik

Pripp

et al. 2017

Research in Autism Spectrum Disorders

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“…Sebagian besar spektrum anak dengan GSA akan menetap sampai dewasa, sehingga berpotensi mengalami berbagai masalah seperti masalah hidup secara mandiri, masalah pekerjaan, gangguan interaksi sosial, gangguan komunikasi, masalah gangguan perilaku, dan kesehatan mental (Vernhet, Dellapiazza, Blanc, Cousson, & Stéphanie, 2018). Tujuan utama penatalaksanaan adalah untuk meminimalkan disabilitas yang terkait, dan memaksimalkan fungsinya agar tidak bergantung terhadap orang lain (Lobar, 2016). Penatalaksanaan anak dengan GSA hingga saat ini banyak mengalami kemajuan mulai dari penatalaksanaan perilaku, teknik visualisasi, pengaturan diet dan nutrisi, dukungan psikologi pada anak dan keluarga, dan penatalaksanaan farmakologi (Mcdonnell et al, 2015).…”

Section: Gangguanunclassified

The Relationship of Visual Support Toward The Clinical Improvement In Children With Autism Spectrum Disorders

Koesdiningsih¹,

Basoeki

Febriyana

et al. 2019

JBE

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Background: The prevalence of autism spectrum disorders (ASD) has increased in the last 30 years from 0.04 to 0.50. This condition increase the parents’ awareness and understanding in early diagnosis, education, management and health services for children with ASD. Purpose: This study aims to analyze the relationship between the uses of visual support for clinical improvement of children with ASD. Method: This study is an observational analytic study. The research was conducted at UPTD ABK Sidoarjo from March to June 2018. The research subjects in this study were four to seven years children with ASD condition. The sampling technique was consecutive sampling and was accomplished during the pre-test and post-test design. The measurement tool for using the Indonesian version of childhood autism rating scale (CARS) that has been validated. Management of visual support has been done for 120 minutes in three months (12 times) consisted of six activities, each activity for 20 minutes with one-one technique (one subject with one therapist). Results: There was no relationship improvement of the CARS based on the pre and post visual support management for three months (12 times) on general impression data, level, and consistency of intellectual responses. The results of paired t-test on the pre and post visual support management for three months (12 times) showed decreasing value of CARS. This result means that social, communication and psychomotor interactions have p<0.01. Conclusion: Management of visual support is associated with clinical improvement in social interaction, communication (non-verbal) and psychomotor (especially gross motoric).

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DSM-V Changes for Autism Spectrum Disorder (ASD): Implications for Diagnosis, Management, and Care Coordination for Children With ASDs

Cited by 42 publications

References 23 publications

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty

School refusal behaviour: Are children and adolescents with autism spectrum disorder at a higher risk?

The Relationship of Visual Support Toward The Clinical Improvement In Children With Autism Spectrum Disorders

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