DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1)

Misdrahi, D.; Vila, Gilbert; Funk-Brentano, I.; Tardieu, Marc; Blanche, Stéphane; Mouren-Siméoni, M. C.

doi:10.1016/j.eurpsy.2003.06.009

Cited by 45 publications

(24 citation statements)

References 6 publications

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“…Attention-deficit/hyperactivity disorder (ADHD) has been reported to be the most common psychiatric diagnosis among perinatally infected youths, ages 5-12 (Havens et al 1994), a finding later confirmed in a study conducted by the Women and Infant Transmission Study Group (Mellins et al 2003). More recently, depression and attentional disorders have been reported to be a common psychiatric manifestation in HIV-infected youth ages 6-15 with a possible association between depression and the presence of HIV encephalopathy (Misdrahi et al 2004).…”

Section: Introductionsupporting

confidence: 54%

“…Consequently, most perinatally HIV-infected children are surviving into their adolescent and young adult years (Gortmaker et al 2001). Unfortunately, data suggest that in this population of survivors there is a high rate of psychiatric symptoms (Havens et al 1994;Battles and Wiener 2002;New et al 2003;Mellins et al 2003;Misdrahi et al 2004;Wiener and Battles, in press) and psychiatric hospitalizations (Gaughan et al 2004) compared with the general pediatric population (Lewinsohn et al 1993;Reinherz et al 1993;Shaffer et al 1996;Olfson et al 2005). Little is known about psychotropic medication use among a cohort of adolescent survivors receiving long-term HIV treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Rather, investigations have focused on factors found to be associated with adverse psychological and behavioral outcomes such as encephalopathy and worsening immune function (Misdrahi et al 2004), negative life events (Bose et al 1994), maternal loss, limited social support (Battles and Wiener 2002), disclosure, (Wiener and Battles, in press;Gaughan et al 2004;Lester et al 2002) or other environmental factors (Mellins et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Psychotropic Medication Use in Human Immunodeficiency Virus-Infected Youth Receiving Treatment at a Single Institution

Wiener

Battles

Ryder

et al. 2006

Journal of Child and Adolescent Psychopharmacology

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A cross sectional study designed to document the use of psychotropic medication in a population of HIV-infected children and adolescents (N = 64) found 45% of the sample had been prescribed at least one psychotropic medication over a 4-year period. The most common medication category prescribed was antidepressants (30%) followed by stimulant type medications (25%). This study suggests that psychotropic medications are commonly prescribed to HIV-infected children and adolescents. Close partnership with mental health professionals to develop treatment approaches for psychiatric disorders in youth living with HIV is recommended.

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Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychotropic Medication Use in Human Immunodeficiency Virus-Infected Youth Receiving Treatment at a Single Institution

Wiener

Battles

Ryder

et al. 2006

Journal of Child and Adolescent Psychopharmacology

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“…This study was limited by small sample sizes and few controlled studies. Others suggest that depression and attentional problems are common psychiatric manifestations in HIV-infected youths 6 to 15 years old [20]. One study described higher rates of psychiatric hospitalization among perinatally infected children and adolescents compared with their non-HIVinfected peers and noted that the primary reasons for admission include depression and behavioral problems (eg, ADHD and oppositional defiant disorder) [21].…”

Section: Psychopathology and Hiv Diseasementioning

confidence: 98%

HIV in adolescents: What we know and what we need to know

Benton

Ifeagwu²

2008

Curr Psychiatry Rep

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HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe and Central Asia. Mother-to-child transmission occurs rarely with antiretroviral treatments in the United States, and congenitally infected children are living to adulthood. HIV is now a "youth-driven disease" worldwide. In the United States, 40% of new HIV infections occur in individuals less than 25 years old, and HIV is the sixth-leading cause of death among adolescents. Young people with HIV/AIDS live with this chronic condition and its associated medical and psychological morbidities while coping with identity and maturation issues. In this paper, we review what we know about HIV and psychiatric disorders among adolescents.

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“…[1][2][3] Although there are a number of studies that document the prevalence of psychological symptoms among children living with HIV, [4][5][6][7] there are fewer that address this issue among adolescents, and none with a large cohort of behaviorally infected youth in this era of simplified treatment regimens. Examination of psychological symptoms and emotional distress among adolescents living with HIV is critical because they are associated with worse quality of life, 8,9 poorer health, 8,10 less adherence to antiretroviral medication (increasing the likelihood for secondary transmission of HIV), [11][12][13][14] greater substance use, 6,[15][16][17] and more sexual risk behavior.…”

mentioning

confidence: 99%

Psychological Symptoms Among 2032 Youth Living with HIV: A Multisite Study

Brown

Whiteley

Harper³

et al. 2015

AIDS Patient Care and STDs

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This study determined the prevalence and patterns of psychological symptoms in adolescents and young adults living with HIV (YLWH) in medical care and relationships between psychological symptoms, route and duration of infection, and antiretroviral treatment (ART). A clinic-based sample of 2032 YLWH (mean age 20.3 years), recruited from 20 adolescent medicine HIV clinics, completed a cross-sectional survey of health behaviors and psychological symptoms using the Brief Symptom Inventory (BSI). Overall, 17.5% of youth reported psychological symptoms greater than the normative threshold on the Global Severity Index. A wide variety of symptoms were reported. The prevalence of clinical symptoms was significantly greater in youth with behaviorally acquired HIV compared to those with perinatally acquired infection (20.6% vs. 10.8%, OR = 2.06 in Multiple Logistic Regression (MLR)), and in those not taking ART that had been prescribed (29. 2% vs. 18.8%, OR = 1.68 in MLR). Knowing one's HIV status for more than one year and disclosure of HIV status were not associated with fewer symptoms. A large proportion of YLWH have psychological symptoms and the prevalence is greatest among those with behaviorally acquired infection. The high rate of psychological symptoms for youth not taking ART that is prescribed is a cause for concern. Symptoms do not appear to be a transient reaction to diagnosis of HIV.

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DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1)

Abstract: - The very low % of CD4 lymphocytes of these children suggest that the appearance of a psychiatric complication should be regarded as a factor indicating severe HIV infection. Depressive disorders may be a clinical form of encephalopathy.

Cited by 45 publications

References 6 publications

Psychotropic Medication Use in Human Immunodeficiency Virus-Infected Youth Receiving Treatment at a Single Institution

Psychotropic Medication Use in Human Immunodeficiency Virus-Infected Youth Receiving Treatment at a Single Institution

HIV in adolescents: What we know and what we need to know

Psychological Symptoms Among 2032 Youth Living with HIV: A Multisite Study

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