“…Religiosity (defined as the salience of religious experience in a person's life) has been associated with higher OCD symptoms, regardless of religion, and will thus also be explored within this multicultural study context. Finally, we will capitalize on this large and international sample to collect qualitative data with the Cultural Formulation Interview (CFI) [92] to explore the role of culture in the presentation and understanding of illness in those with OCD.…”
Section: Why Include Environmental Variables In a Brain Imaging Study?mentioning
confidence: 99%
“…These measures are shown in Table 2 and include semi-structured interviews performed by a trained rater and self-report questionnaires. We will also collect qualitative data using the Cultural Formulation Interview (CFI) [92] to explore the role of culture in the presentation and understanding of illness in those with OCD.…”
Background: Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2-3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in this paper is to identify robust and reproducible brain signatures of measurable behaviors and clinical symptoms that are common in individuals with OCD. A global approach was chosen to accelerate discovery, to increase rigor and transparency, and to ensure generalizability of results. Methods: We will study 250 medication-free adults with OCD, 100 unaffected adult siblings of individuals with OCD, and 250 healthy control subjects at five expert research sites across five countries (Brazil, India, Netherlands, South Africa, and the U.S.). All participants will receive clinical evaluation, neurocognitive assessment, and magnetic resonance imaging (MRI). The imaging will examine multiple brain circuits hypothesized to underlie OCD behaviors, focusing on morphometry (T1-weighted MRI), structural connectivity (Diffusion Tensor Imaging), and functional connectivity (resting-state fMRI). In addition to analyzing each imaging modality separately, we will also use multi-modal fusion with machine learning statistical methods in an attempt to derive imaging signatures that distinguish individuals with OCD from unaffected siblings and healthy controls (Aim #1). Then we will examine how these imaging signatures link to behavioral performance on neurocognitive tasks that probe these same circuits as well as to clinical profiles (Aim #2). Finally, we will explore how specific environmental features (childhood trauma, socioeconomic status, and religiosity) moderate these brain-behavior associations.
“…Religiosity (defined as the salience of religious experience in a person's life) has been associated with higher OCD symptoms, regardless of religion, and will thus also be explored within this multicultural study context. Finally, we will capitalize on this large and international sample to collect qualitative data with the Cultural Formulation Interview (CFI) [92] to explore the role of culture in the presentation and understanding of illness in those with OCD.…”
Section: Why Include Environmental Variables In a Brain Imaging Study?mentioning
confidence: 99%
“…These measures are shown in Table 2 and include semi-structured interviews performed by a trained rater and self-report questionnaires. We will also collect qualitative data using the Cultural Formulation Interview (CFI) [92] to explore the role of culture in the presentation and understanding of illness in those with OCD.…”
Background: Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2-3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in this paper is to identify robust and reproducible brain signatures of measurable behaviors and clinical symptoms that are common in individuals with OCD. A global approach was chosen to accelerate discovery, to increase rigor and transparency, and to ensure generalizability of results. Methods: We will study 250 medication-free adults with OCD, 100 unaffected adult siblings of individuals with OCD, and 250 healthy control subjects at five expert research sites across five countries (Brazil, India, Netherlands, South Africa, and the U.S.). All participants will receive clinical evaluation, neurocognitive assessment, and magnetic resonance imaging (MRI). The imaging will examine multiple brain circuits hypothesized to underlie OCD behaviors, focusing on morphometry (T1-weighted MRI), structural connectivity (Diffusion Tensor Imaging), and functional connectivity (resting-state fMRI). In addition to analyzing each imaging modality separately, we will also use multi-modal fusion with machine learning statistical methods in an attempt to derive imaging signatures that distinguish individuals with OCD from unaffected siblings and healthy controls (Aim #1). Then we will examine how these imaging signatures link to behavioral performance on neurocognitive tasks that probe these same circuits as well as to clinical profiles (Aim #2). Finally, we will explore how specific environmental features (childhood trauma, socioeconomic status, and religiosity) moderate these brain-behavior associations.
“…Awareness and acknowledgement of the cultural differences which can influence behaviors and reports of behaviors are needed for more effective and culturally informed interviewing. Other suggestions include incorporating culturally sensitive diagnostic tools to more accurately assess youth, in particular the DSM's Cultural Formulation Interview [16,77]. These tools can help clinicians more effectively assess cultural, environmental, and social influences of behaviors in order to distinguish behavioral manifestations of stress, trauma, and underlying mental health conditions.…”
“…63,69,82 It is a mestiza discipline because, as the active receptacle of different trends and contributions from other parts of the world, it seems to be elaborating its own synthesis in an ongoing ''syncretic'' process. 83 This mestizaje gives Latin American psychiatry a peculiarly mixed tonality in clinical conceptualizations (including the so-called ''cultural syndromes''), 50,76,79,84 diagnostic practices, and therapeutic approaches, a fact that can also be considered part of a subtle but pervasively ongoing globalization process. The second characteristic, its social scope, is dictated not only by demographic and economic realities, but also by traditions that enhance sociocentrism or communalism, friendship-and familybased practices, hierarchically-inspired respect for parental as well as elderly and other types of authority, and persistence of some rural life habits.…”
The multi-faceted phenomenon known as globalization has a particular impact on the conceptual and practical development of mental health disciplines in general, and psychiatry in particular, across different world regions. To be theoretically and functionally effective, global psychiatry requires an integration of its different components. To such objective, and after a brief review of continental European and Anglo-Saxon contributions, this article examines the history, characteristics, and contributions of Latin/Iberian American and Spanish-speaking psychiatry, in order to substantiate its role in world psychiatry. The Latin American proper (including Portuguese-speaking Brazil), Spain, and U.S.-based Hispanic components are described, revealing an identity that is based on a humanistic tradition, a value-based, culturally-determined clinical approach to patient care, and a pragmatic adaptation of different treatment resources and techniques. These may constitute supportive elements of an instrumental interregional bond in the present and future of our discipline.
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