DSIMS characterization of a drug-containing polymer-coated cardiovascular stent

Verhoeven, Marjolein; Driessen, A. A.; Paul, Asha; Brown, Andrew F.; Canry, Jean-Claude; Hendriks, Marc

doi:10.1016/j.jconrel.2004.01.014

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…In addition, the sputter rate is significantly reduced when employing atomic beams, such that only dynamic SIMS instruments are typically used. There are several examples of polymeric depth profiling with atomic beams including PS (Whitlow & Wool, 1989, 1991Zhao et al, 1991;Shwarz et al, 1992;Liu et al, 1995;Zheng et al, 1995;Strzhemechny et al, 1997;Rysz et al, 1999;Yokoyama et al, 1999;Shin et al, 2001;Hu et al, 2003;Lin et al, 2003;Harton, Stevie, & Ade, 2006a,b,c;Harton et al, 2006d), PAMA (Valenty et al, 1984), PBMA (Verhoeven et al, 2004), PEVA (Verhoeven et al, 2004), PC (Valenty et al, 1984), PVDF (Chujo, 1991), PEO (Mattsson et al, 2000;Huang et al, 2001), PMMA (Chujo, 1991;Huang et al, 2001;Hu et al, 2003;Harton, Stevie, & Ade, 2006a,b,c;Harton et al, 2006d), polydimethyl phenylene oxide (PDPO) (Lin et al, 2003), PVP (Zheng et al, 1995;Pinto, Novak, & Nicholas, 1999;Yokoyama et al, 1999;Harton, Stevie, & Ade, 2006a,b;Harton et al, 2006d), PPV and other polymer based LED materials Bulle-Lieuwma & van de Weijer, 2006), solar cell materials (Bulle-Lieuwma et al, 2003), conducting polymers (Gray et al, 1992), video tapes (Chujo, 1991), silicones …”

Section: B Atomic Ion Bombardment Of Polymersmentioning

confidence: 99%

Cluster secondary ion mass spectrometry of polymers and related materials

Mahoney

2009

Mass Spectrometry Reviews

283

329

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Cluster secondary ion mass spectrometry (cluster SIMS) has played a critical role in the characterization of polymeric materials over the last decade, allowing for the ability to obtain spatially resolved surface and in-depth molecular information from many polymer systems. With the advent of new molecular sources such as C(60)(+), Au(3)(+), SF(5)(+), and Bi(3)(+), there are considerable increases in secondary ion signal as compared to more conventional atomic beams (Ar(+), Cs(+), or Ga(+)). In addition, compositional depth profiling in organic and polymeric systems is now feasible, without the rapid signal decay that is typically observed under atomic bombardment. The premise behind the success of cluster SIMS is that compared to atomic beams, polyatomic beams tend to cause surface-localized damage with rapid sputter removal rates, resulting in a system at equilibrium, where the damage created is rapidly removed before it can accumulate. Though this may be partly true, there are actually much more complex chemistries occurring under polyatomic bombardment of organic and polymeric materials, which need to be considered and discussed to better understand and define the important parameters for successful depth profiling. The following presents a review of the current literature on polymer analysis using cluster beams. This review will focus on the surface and in-depth characterization of polymer samples with cluster sources, but will also discuss the characterization of other relevant organic materials, and basic polymer radiation chemistry.

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Section: B Atomic Ion Bombardment Of Polymersmentioning

confidence: 99%

Cluster secondary ion mass spectrometry of polymers and related materials

Mahoney

2009

Mass Spectrometry Reviews

283

329

View full text Add to dashboard Cite

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“…The porcine stented arterial segments were excised at different time points, and the amount of residual drug on the stent was measured using high‐performance liquid chromatography technique. The description of this technique, which is very commonly used to determine release rates of drugs from stent coatings,20–22 is not discussed here. The residual amount of drug in the stent coating at a particular time point is subtracted from the total amount of drug in the stent at time t = 0 to determine the amount of drug released from the stent till that time point.…”

Section: Methodsmentioning

confidence: 99%

A mathematical model for predicting drug release from a biodurable drug‐eluting stent coating

Hossainy

Prabhu

2008

J Biomedical Materials Res

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Drug-eluting stents (DESs) are drug-device combination products that have been commercialized and demonstrated to be safe and efficacious in treating coronary artery disease. They have been very effective in reducing the extent of neointimal hyperplasia and therefore in preventing or minimizing the occurrence of in-stent restenosis. In order to develop a successful DES, it is imperative that the coating be designed so as to deliver, after stent implantation, a therapeutic dose of the drug for the desired time duration at the site of the arterial blockage. Mathematical models are very valuable tools that can be used to study the effect of different coating parameters on drug delivery and can therefore help in coating design. We have developed a bimodal lumped-parameter mass transport model to describe the release of the drug everolimus from a biodurable fluoropolymer-based DES coating. We assume that the dispersed drug phase contributes to two discrete modes of drug transport through the coating. These are the fast mode (mode I) which is the release of the drug from a highly percolated structure of drug phase within the polymer, and the slow mode (mode II) which is the release of the drug from a nonpercolated, polymer-encapsulated phase of the drug within the coating. The three coefficients in the governing equations describing the model, i.e. the two effective diffusivities corresponding to each of the two modes and the fraction of the drug in one of the two modes, were determined by fitting with available DES release data. The predictive power of the model is demonstrated by comparing the release rate from different coating configurations (thickness and drug to polymer ratios) with experimental data. Also, it is demonstrated that if limited experimental data are available at early time points, the model can be used to predict drug release at subsequent time points.

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“…The stent coatings need to satisfy many of the physical, biological, and regulatory criteria before they can be deemed suitable, therefore, the most important factir is to choose a suitable and convenient method for coating the stent. The coating solution is often applied to the stent in the traditional manner in which liquid solution is applied, such as, dipping, spraying, or brushing 26–28. Of late, the layer‐by‐layer (LBL) assembly technology, a technique in which nanoscale layers of polyanions and polycations are dipped onto a charged surface from aqueous baths, constitutes a powerful tool, with applications ranging from electrochemical thin films to biocatalysis 29.…”

Section: Introductionmentioning

confidence: 99%

Layer‐by‐layer assembly of chitosan and platelet monoclonal antibody to improve biocompatibility and release character of PLLA coated stent

Luo

Wang

et al. 2011

J Biomedical Materials Res

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The aim of this study is to construct a biocompatible coating of a drug-eluting stent through the incorporation of chitosan with monoclonal antibody (mAb) to a platelet glycoprotein (GP) IIIa receptor, by electrostatic layer-by-layer (LBL) adsorption of oppositely charged polyelectrolytes and proteins. The platelet maximum aggregation rate and aggregation inhibition rate tests confirm the bioactivity of mAb in different pH assembly environments. The fluorescence spectra test and confocal laser scanning microscopy observation were used to monitor the LBL assembly process of the mAb/chitosan multilayer on the surface of the aminolyzed Poly-L-lactic acid (PLLA) membrane, when using Rhodamine B isothiocyanate-labeled mAb and Fluorescein isothiocyanate-labeled chitosan. The in vitro platelet adhesion experiment demonstrated the amicable blood compatibility of the mAb/chitosan multilayer. The endothelial cell adhesion and migration test revealed that the multilayer could improve the cytocompatibility of the PLLA matrix in terms of cell attachment, proliferation, and migration. An in vitro perfusion circuit was designed to evaluate the release rates measured by a radioisotope technique with ¹²⁵I-labeled GP IIIa mAb. The different eluting curves of the mAb/chitosan-assembled stent and mAb physically absorbed stent showed the improvement of mAb's release character when using LBL self-assembly technology. Our method to prepare a biocompatible stent surface with mAb/chitosan multilayers has proved to be favorable and effective in vitro, thus justifying further evaluation to improve the biocompatibility in an animal model test.

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DSIMS characterization of a drug-containing polymer-coated cardiovascular stent

Cited by 13 publications

References 11 publications

Cluster secondary ion mass spectrometry of polymers and related materials

Cluster secondary ion mass spectrometry of polymers and related materials

A mathematical model for predicting drug release from a biodurable drug‐eluting stent coating

Layer‐by‐layer assembly of chitosan and platelet monoclonal antibody to improve biocompatibility and release character of PLLA coated stent

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