2003
DOI: 10.1007/s00438-003-0956-6
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DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe

Abstract: Meiosis is initiated from the G1 phase of the mitotic cell cycle, and consists of pre-meiotic S-phase followed by two successive nuclear divisions. Here we show that control of gene expression during pre-meiotic S-phase in the fission yeast Schizosaccharomyces pombe is mediated by a DNA synthesis control-like transcription factor complex (DSC1), which acts upon M lu1 cell cycle box (MCB) promoter motifs. Several genes, including rec8+, rec11+, cdc18+, and cdc22+, which contain MCB motifs in their promoter regi… Show more

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Cited by 17 publications
(11 citation statements)
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“…These findings suggest that there are a discrete number of transcription factors that control meiotic genes and hence the regulation of meiotic progression in bread wheat, as has been suggested for yeast [49,50]. In order to further our understanding of meiotic regulation and determine whether any of these candidates are co-regulated, a yeast one-hybrid approach could be employed using the promoter regions of the candidates.…”
Section: Resultsmentioning
confidence: 86%
“…These findings suggest that there are a discrete number of transcription factors that control meiotic genes and hence the regulation of meiotic progression in bread wheat, as has been suggested for yeast [49,50]. In order to further our understanding of meiotic regulation and determine whether any of these candidates are co-regulated, a yeast one-hybrid approach could be employed using the promoter regions of the candidates.…”
Section: Resultsmentioning
confidence: 86%
“…We examined the timing of meiotic transcript accumulation, which occurs in characteristic waves (Mata et al, 2007). Early meiotic gene expression depends in part on the meiosis-specific DNA synthesis control-like transcription factor complex (DSC1) (Cunliffe et al, 2004; Mata et al, 2007), which regulates rec12 + , dfp1 + , and numerous other genes. There is also DSC1-independent early transcription of several genes including rec25 + and rec27 + (Mata et al, 2007).…”
Section: Resultsmentioning
confidence: 99%
“…Normal meiosis in the fission yeast requires the induction of a number of "tightly" meiosisspecific genes following meiotic commitment (55); for example, rec8, a gene encoding a meiosis-specific cohesin component (56). During mitotic proliferation, these genes are suppressed at the transcriptional and posttranscriptional levels through an RNA interference-and exosome-dependent pathway controlled by the Mmi1 protein (57)(58)(59)(60)(61)(62). Dysregulation of the Mmi1 pathway in mitotically dividing cells results in inappropriate levels of meiosis-specific transcripts such as rec8 mRNA (59).…”
Section: Activation Of Meiotic Functions In Cancer Cellsmentioning
confidence: 99%