DSC study and phase diagrams calculation of binary systems of paracetamol

Klímová, Kateřina; Leitner, J.

doi:10.1016/j.tca.2012.09.024

Cited by 50 publications

(21 citation statements)

References 38 publications

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“…The DSC scans from a thermal cycle of acetaminophen and ALD Al2O3 and TiO2 (TiCl4) coated acetaminophen powders are shown in Figure 2a. Thermal cycling of acetaminophen has been extensively reported in the literature, providing support for this analysis (Sacchetti, 2001;Rossi et al, 2003;Ledru et al, 2007;Trasi and Taylor, 2012;Klímová and Leitner, 2012). The thermograph ALD coating process it is unlikely that the existing form I would transform into form II.…”

Section: Dscmentioning

confidence: 54%

Surface modification of acetaminophen particles by atomic layer deposition

Kääriäinen

Kemell

Vehkamäki

et al. 2017

International Journal of Pharmaceutics

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Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD, utilizing common chemistries for Al2O3, TiO2 and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating process and maintains its stable polymorphic structure. Acetaminophen with nanometer scale ALD coatings shows slowed drug release. ALD TiO2 coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the most cytotoxicity among the ALD materials under study when assessed in vitro by their effect on intestinal Caco-2 cells.

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Section: Dscmentioning

confidence: 54%

Surface modification of acetaminophen particles by atomic layer deposition

Kääriäinen

Kemell

Vehkamäki

et al. 2017

International Journal of Pharmaceutics

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“…The DSC curve of pure CAF exhibited a single endothermic peak at 235.5 C which corresponding to crystalline CAF melting point. 34,35 As amorphous polymers, FG did not show any fusion peaks or phase transitions. In the case of CAF loaded FG lm, there was an endothermic peak of crystal CAF melting peak which indicates the crystallization during the slow water evaporation process.…”

Section: 30mentioning

confidence: 88%

Fish gelatin nanofibers prevent drug crystallization and enable ultrafast delivery

et al. 2017

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For drug delivery, uncontrolled drug crystallization is the most important and well-described problem which affects the compatibility between target drug and carrier polymer matrix. The crystallization of drugs makes a drug delivery system unstable and it causes a drop the drug loading efficiency and unpredictable release behavior. Recently, the electrospinning process which has rapid solvent evaporation speed has been proposed to prevent the drug crystallization during the drug loading process. In the present study, a fastdissolving nanofibrous drug delivery carrier was prepared via electrospinning of aqueous fish gelatin as the polymer carrier and caffeine as the hydrophilic model drug under environmentally friendly conditions. Fish gelatin electrospinning was able to produce caffeine loaded gelatin nanofibers with a diameter of 200-220 nm. The X-ray diffraction (XRD) and differential scanning calorimetry (DSC) data clearly showed that the amorphous state of caffeine was well incorporated into ultrafine nanofibrous carrier whereas crystalline caffeine was dispersed into conventional fish gelatin film. Fish gelatin nanofibers were able to load two times more caffeine (20 mg ml À1) than conventional caffeine-loaded polymer nanofibers. The fish gelatin nanofibrous mat has good flexibility compared to film due to its interporous nanofiber network. The fish gelatin nanofibrous mats disintegrated within 1.5 s, 27 times faster than films. Fish gelatin nanofibers also showed that most caffeine was released within 10 seconds, which is faster than fish gelatin film and free caffeine drugs. These fish gelatin nanofibers showed 10 times faster caffeine release rates than other caffeine loaded polymer nanofibers. Electrospun fish gelatin nanofibrous mats can be used in biomedical fields especially for the ultra fast delivery of hydrophilic drugs or active ingredients.

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“…44 Thermograms after differential scanning calorimetry of pure ibuprofen and co-processed powder samples are presented in Fig 3. Ibuprofen has shown the melting endotherm at 76.7 °C which is approximately similar to the literature value. 33 With the increase of MTS amount in the co-processed material melting temperature and enthalpy (data not mentioned) have been decreased markedly signifying the material is made up of a number of smaller crystals or crystallites, and paracrystalline phases.…”

Section: Characterization By Scanning Electron Microscopy and Diffmentioning

confidence: 99%

Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

Acharya¹,

Mishra²,

Sahoo³

et al. 2017

ACSi

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Assessment of interactions of ibuprofen and magnesium trisilicate after co-processing has been carried out by infrared spectroscopy. Dry-state ball-milling and, aqueous state kneading and freeze-drying were performed. FTIR spectroscopy of co-processed materials described acid-base reaction between the carboxylic acid containing ibuprofen to a significant extent. Increased absorbance of carboxylate peak accompanied by a consistently reduced absorbance of the carbonyl acid peak was evident. Absorbance of carboxylate peak was more in freeze-dried sample compared to milled product. Intermolecular hydrogen bonding between ibuprofen and magnesium trisilicate in the co-processed material has been suggested. Inhibition of crystal morphology has been noticed in the photomicrographs of both the products. DSC report has shown absence or significantly decreased melting endotherm representing almost complete amorphization of ibuprofen. Release of drug increased greatly after co-processing in comparison to crystalline ibuprofen. Freeze-dried samples have improved drug release more significantly compared to ball-milled samples.

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DSC study and phase diagrams calculation of binary systems of paracetamol

Cited by 50 publications

References 38 publications

Surface modification of acetaminophen particles by atomic layer deposition

Surface modification of acetaminophen particles by atomic layer deposition

Fish gelatin nanofibers prevent drug crystallization and enable ultrafast delivery

Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

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