DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples
Fenglong Jiao,
Clinton Yu,
Andrew Wheat
et al.
Abstract:Protein–protein
interactions (PPIs) are fundamental to understanding
biological systems as protein complexes are the active molecular modules
critical for carrying out cellular functions. Dysfunctional PPIs have
been associated with various diseases including cancer. Systems-wide
PPI analysis not only sheds light on pathological mechanisms, but
also represents a paradigm in identifying potential therapeutic targets.
In recent years, cross-linking mass spectrometry (XL-MS) has emerged
as a powerful tool for def… Show more
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