Dry Skin in Childhood and the Misery of Eczema and Its Treatments

Lewis-Jones, Sue

doi:10.1007/978-3-642-27606-4_4

Treatment of Dry Skin Syndrome 2012

DOI: 10.1007/978-3-642-27606-4_4

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Dry Skin in Childhood and the Misery of Eczema and Its Treatments

Sue Lewis-Jones

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Cited by 6 publications

References 84 publications

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A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin

Djokic-Gallagher¹,

Rosher²,

Oliveira³

et al. 2017

Dermatol Ther (Heidelb)

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IntroductionHealthcare professionals tend to recommend emollients based primarily on patient/consumer preference and cost, with cheaper options assumed to be therapeutically equivalent. The aim of this study was therefore to compare the effects on skin hydration of two emollients prescribed in the UK, Doublebase Dayleve™ gel (DELP) and a cheaper alternative, Zerobase Emollient™ cream (ZBC).MethodsThis was a single-centre, randomised, double-blind, concurrent bi-lateral (within-patient) comparison in 18 females with atopic eczema and dry skin on their lower legs. DELP gel and ZBC cream were each applied to one lower leg twice daily for 4 days and on the morning only on day 5. The efficacy of both products was assessed by hydration measurements using a Corneometer CM825 probe (Courage-Khazaka Electronic). The measurements were made three times daily on days 1 to 5. The primary efficacy variable was the area under the curve (AUC) of the change from baseline corneometer readings over the 5 days.ResultsSkin hydration using DELP gel was significantly higher than using ZBC cream (p < 0.0001). The cumulative increase in skin hydration observed for DELP gel was substantial and long lasting. In contrast, for ZBC cream, there was no significant improvement of the cumulative skin hydration as measured by the AUC (p = 0.22).ConclusionDELP gel achieved substantial, long-lasting and cumulative skin hydration, whilst ZBC cream achieved no measurable improvement in skin hydration compared to before treatment. Healthcare professionals should be aware that different emollients can perform differently.FundingDermal Laboratories Ltd.Trial RegistrationEudraCT number:2014-001026-16.

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A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin

Djokic-Gallagher¹,

Rosher²,

Oliveira³

et al. 2017

Dermatol Ther (Heidelb)

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Infant massage: The practice and evidence-base to support it

Cooke

2015

British Journal of Midwifery

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Infant dry skin: Clinical practice and the evidence to support it

Cooke

2018

British Journal of Midwifery

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Parental concern over infant dry skin is a common challenge that midwives and other maternity professionals frequently address in the early postnatal period. Although infant dry skin is a normal process of adaptation to extra-uterine life, parents often wish to treat it, and there is uncertainty among health professionals about what is safe and best practice. For decades, health professionals have recommended the use of topical natural oils to prevent or treat infant dry skin, but more recently, there has been increasing concern that use of these oils on the skin may be a contributory factor in the rising prevalence of childhood atopic eczema. This article will consider how infant skin may be affected by topical products, the role of the health professional giving infant skin care advice and current evidence to support clinical practice.

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Dry Skin in Childhood and the Misery of Eczema and Its Treatments

Cited by 6 publications

References 84 publications

A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin

A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin

Infant massage: The practice and evidence-base to support it

Infant dry skin: Clinical practice and the evidence to support it

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