Dry Powder Inhaler Device Influence on Carrier Particle Performance

Donovan, Martín J.; Kim, Sin Hyen; Raman, Venkat; Smyth, Hugh D. C.

doi:10.1002/jps.22824

Cited by 103 publications

(67 citation statements)

References 28 publications

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“…While the CFD simulations shown are calculated for 39 l/min, these data are representative of the static pressures acting in the device and capsule and air velocity magnitude at 20 and 55 l/min. These data suggest that the dimensions of this orifice primarily determine the resistance of the HandiHaler, which has also been suggested by Donovan et al (17).…”

Section: Cfd Modeling Of the Handihalersupporting

confidence: 82%

“…Above the capsule chamber is a metallic convex mesh, which sits over the by-pass inlets and the capsule. Donovan et al have reported a similar CFD model of the HandiHaler (17).…”

Section: Cfd Modeling Of the Handihalermentioning

confidence: 90%

“…Computational fluid dynamics (CFD) is an established methodology for predicting the flow properties and the fate of the particulate system in the respiratory tract and inhalation devices (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). For example, Coates et al demonstrated how CFD modeling of the DPI mouthpiece geometry, dispersion grid and air inlet size (11), airflow rate (12), and capsule properties (13) could be used to investigate aerosol performance.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the recent work by Donovan et al utilized CFD to investigate the aerosolization performance of carrier particles of different physical properties in the Aerolizer and HandiHaler. They found that in comparison to the HandiHaler, the aerosolization performance of the Aerolizer was more dependent on the carrier particle size, which appeared to be related to a greater number of carrier particle-inhaler collisions (17). Despite these studies, there are no examples that utilize CFD modeling to define device design parameters, in order to achieve in vitro comparability of two different unit-dose, capsule-based DPI devices of different designs across multiple flow rates.…”

Section: Introductionmentioning

confidence: 99%

“…The HandiHaler and Cyclohaler differ in terms of both the device resistance and airflow behavior. The specific resistance of the Cyclohaler (0.018 kPa 0.5 /(l min ) (17,21). The development of the two additional test DPI devices (referred to as Mod 1 and Mod 2) was based on the Cyclohaler platform with knowledge gained from the CFD simulations of the Cyclohaler, as explained below.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers

Shur

Lee

Adams

et al. 2012

AAPS J

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Abstract. This study investigated the effect of modifying the design of the Cyclohaler on its aerosolization performance and comparability to the HandiHaler at multiple flow rates. The Cyclohaler and HandiHaler were designated as model test and reference unit-dose, capsule-based dry powder inhalers (DPIs), respectively. The flow field, pressure drop, and carrier particle trajectories within the Cyclohaler and HandiHaler were modeled via computational fluid dynamics (CFD). With the goal of achieving in vitro comparability to the HandiHaler, the CFD results were used to identify key device attributes and to design two modifications of the Cyclohaler (Mod 1 and Mod 2), which matched the specific resistance of the HandiHaler but exhibited different cyclonic flow conditions in the device. Aerosolization performance of the four DPI devices was evaluated by using the reference product's capsule and formulation (Spiriva capsule) and a multistage cascade impactor. The in vitro data showed that Mod 2 provided a closer match to the HandiHaler than the Cyclohaler and Mod 1 at 20, 39, and 55 l/min. The in vitro and CFD results together suggest that matching the resistance of test and reference DPI devices is not sufficient to attain comparable aerosolization performance, and the improved in vitro comparability of Mod 2 to the HandiHaler may be related to the greater degree of similarities of the flow rate of air through the pierced capsule (Q c ) and the maximum impact velocity of representative carrier particles (V n ) in the Cyclohaler-based device. This investigation illustrates the importance of enhanced product understanding, in this case through the CFD modeling and in vitro characterization of aerosolization performance, to enable identification and modification of key design features of a test DPI device for achieving comparable aerosolization performance to the reference DPI device.KEY WORDS: computational fluid dynamics; device design; dry powder inhaler; in vitro comparability; in vitro performance.

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Section: Cfd Modeling Of the Handihalersupporting

confidence: 82%

“…Above the capsule chamber is a metallic convex mesh, which sits over the by-pass inlets and the capsule. Donovan et al have reported a similar CFD model of the HandiHaler (17).…”

Section: Cfd Modeling Of the Handihalermentioning

confidence: 90%