This research aimed to evaluate the use of Ca-Soap from black soldier fly (BSF) larvae oil on physiological responses and hematology of male Garut sheep. Fifteen male Garut sheep were allocated into randomized block design with three treatments and five replicates. The treatments were T 0 (control), T 1 = T 0 + 4% Ca-soap, and T 2 = T 0 + 8% Ca-soap. The parameters observed included physiological responses, hematology, and water intake. Data were analyzed using ANOVA, and any significant differences were further tested using Duncan’s multiple range test. The results showed that the supplementation of 8% Ca-soap of BSF larvae oil into the ration caused the respiration rate in the morning to be lower (P < 0.05) compared to control. Treatment had no effect on rectal temperature and heart rate of male Garut sheep. Hematological profiles were not affected by treatments, except that Ca-soap supplementation increased (P < 0.05) lymphocyte count, but decreased (P < 0.05) the neutrophiles/lymphocytes (N/L) ratio of male Garut sheep. Water intake was not affected by Ca-soap supplementation. This study concluded that Ca-soap of BSF larvae oil can be used up to 8% in the ration without any adverse effects. Even, it can improve the immune system of male Garut sheep.