Dry eyes and AIs: If you don't ask you won't find out

Inglis, Holly; Boyle, Frances M.; Friedlander, Michael; Watson, Stephanie

doi:10.1016/j.breast.2015.08.008

Cited by 23 publications

(22 citation statements)

References 37 publications

(25 reference statements)

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“…Our results demonstrated a high prevalence of ocular surface disease‐related symptoms and signs in patients receiving AIs compared to healthy controls, in line with Turaka et al and Inglis et al, who reported dry eye syndrome in AI users . Specifically, patients receiving AIs in our study presented blepharitis in 75%, while MGD was found to be less common (42.5%), but associated with dry eye symptoms.…”

Section: Discussionsupporting

confidence: 90%

“…Recently Inglis et al have found that AI users have a higher prevalence of dry eye syndrome compared to controls, suggesting that routine screening with the ocular surface disease index would be useful for such patients, so as to improve quality of life . In light of the above, the purpose of this study was to investigate the potential impact of AIs on the anterior segment of the eye and especially the ocular surface.…”

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confidence: 99%

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Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors

et al. 2016

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Aromatase inhibitors (AIs) are widely used as adjuvant hormonal therapy in postmenopausal women with hormone receptor-positive breast cancer. The purpose of this study was to investigate the potential impact of AIs on the anterior segment of the eye and especially the ocular surface. Participants in our study were 41 hormone receptor-positive early stage breast cancer patients (80 eyes), treated with AIs, while 80 eyes of 40 age- and gender-matched healthy controls, not previously used AIs for any purpose, were also evaluated. All participants underwent a complete ophthalmological examination, including best corrected visual acuity (BCVA) assessment, slit-lamp biomicroscopy, and dilated fundus examination. Ocular surface disease-related symptoms and signs were also recorded. The most common symptom was found to be blurred vision, while other symptoms included foreign body sensation, tearing, redness, and photophobia. Slit-lamp examination revealed blepharitis and meibomian gland dysfunction in 75% and 42.5% of patients, respectively. Superficial punctate keratitis and conjunctival injection were also present. Our results demonstrated a high prevalence of ocular surface disease-related symptoms and signs in patients receiving AIs compared to healthy controls. This study may raise a flag regarding the use of AIs. However, further and larger prospective longitudinal studies are needed to examine the possible effect of AIs alone or in combination with chemotherapy in the eyes of breast cancer patients.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors

et al. 2016

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“…Estrogens suppress lipid production, and testosterone stimulates lipid production (Peck et al, 2017). Testosterone also provides anti-inflammatory protection (Inglis, Boyle, Friedlander, & Watson, 2015). It is speculated that as testosterone levels decrease in menopausal women, the result is the loss of meibomian gland tissue and thus a loss of lipid production.…”

Section: Discussionmentioning

confidence: 99%

Menopause and Dry Eye Syndrome

Lurati¹

2019

Nursing for Women's Health

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“…It affects up to 1/5 of the population and the prevalence increases with age [7]. Young perimenopausal and menopausal women are more vulnerable to this disease.…”

Section: Introductionmentioning

confidence: 99%

Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Song

Zhang

et al. 2017

Journal of Ophthalmology

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Purpose. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye. Methods. In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score. Results. Our correlation analyses showed that rounding of lid margins, notching of lid margins, vascularity of lid margins, hyperkeratinization, plugging of orifices, main duct dropout, and conjunctival congestion all had a positive correlation with OSDI score, while main duct number (central 1 cm) and BUT had a negative one. Further analysis suggested that these correlations varied in different age groups. Multiple linear regression analysis indicated that main duct number (central 1 cm), rounding of lid margins, and hyperkeratinization significantly affected OSDI score. Conclusions. Close attention should be paid to the morphology and structure of the eyelid margin and the function of meibomian gland in the diagnosis, treatment, and follow-up of dry eye diseases.

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Dry eyes and AIs: If you don't ask you won't find out

Cited by 23 publications

References 37 publications

Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors

Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors

Menopause and Dry Eye Syndrome

Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

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