Dry coating of solid dosage forms: an overview of processes and applications

Foppoli, Anastasia; Cerea, Matteo; Zema, L.; Gazzaniga, A.

doi:10.1080/03639045.2017.1355923

Cited by 26 publications

(61 citation statements)

References 107 publications

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“…Recently, many routes for the dry coating of particles were realized in order to produce advanced materials by coating the surface of larger core (host) particles with fine shell (guest) particles through mechanical forces [83,84]. Among the various routes, mechanofusion (MF) provides an exceptional solution [85] by attaining a considerable capacity to produce composite powders with the desired tailor-made properties for advanced MMCs [42,85,86].…”

Section: Flake Powder Metallurgy High-shear Pre-dispersion and Ssbm (Fpm-hspd/ssbm)mentioning

confidence: 99%

Progress of Flake Powder Metallurgy Research

Sadeghi

Cavaliere

2021

Metals

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This paper reviewed several recent progresses of the new powder metallurgy technology known as flake powder metallurgy (FPM) including different processing routes, conventional FPM (C-FPM), slurry blending (SB), shift-speed ball milling (SSBM), and high-shear pre-dispersion and SSBM (HSPD/SSBM). The name of FPM was derived from the use of flake metal powders obtained by low-speed ball milling (LSBM) from spherical powder. In this case, the uniformity of reinforcement distribution leads to increased strength and ductility. Powder is the basic unit in PM, especially advanced PM, and its control is key to various new PM technologies. The FPM is a typical method for finely controlling the powder shape through low-energy ball milling (LEBM) to realize the preparation of advanced material structures. The present paper represents a review of the main results of research on FPM and indicates the potential for future studies devoted to the optimization of this processing route.

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Section: Flake Powder Metallurgy High-shear Pre-dispersion and Ssbm (Fpm-hspd/ssbm)mentioning

confidence: 99%

Progress of Flake Powder Metallurgy Research

Sadeghi

Cavaliere

2021

Metals

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“…The duration of the lag phase can be programmed by selecting the appropriate type of swellable/soluble hydrophilic polymer, its molecular weight (i.e., viscosity grade) and the thickness of the applied layer. In the case of barriers based on HPMC, different chain lengths and several coating techniques were studied [4,31]. More recently, time-dependent reservoir systems in the form of capsules were proposed [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

Casati

Melocchi

Moutaharrik

et al. 2020

IJMS

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A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were prepared by injection molding of blends of a high-amylose starch and hydroxypropyl methylcellulose (HPMC) of different chain lengths. The dissolution/erosion of the HPMC network assures a time-controlled drug release, i.e., drug release starts upon sufficient shell swelling/dissolution/erosion. In addition, the presence of high-amylose starch ensures enzyme-triggered drug release. Once the colon is reached, the local highly concentrated bacterial enzymes effectively degrade this polysaccharide, resulting in accelerated drug release. Importantly, the concentration of bacterial enzymes is much lower in the upper gastrointestinal tract, thus enabling site-specific drug delivery. The proposed capsules were filled with acetaminophen and exposed to several aqueous media, simulating the contents of the gastrointestinal tract using different experimental setups. Importantly, drug release was pulsatile and occurred much faster in the presence of fecal samples from patients. The respective lag times were reduced and the release rates increased once the drug started to be released. It can be expected that variations in the device design (e.g., polymer blend ratio, capsule shell geometry and thickness) allow for a large variety of possible colon targeting release profiles.

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“…double-compression (press-coating) and spray-coating, were both attempted. Press-coating offered advantages related to its solvent-free nature and, therefore, to the circumvented need for time-and energy-consuming drying steps (Foppoli et al, 2017). For these reasons, it also represented a technique with limited impact on the overall stability of the products.…”

Section: Introductionmentioning

confidence: 99%

Erodible coatings based on HPMC and cellulase for oral time-controlled release of drugs

Foppoli

Maroni

Palugan

et al. 2020

International Journal of Pharmaceutics

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Oral drug delivery systems for time-controlled release, intended for chronotherapy or colon targeting, are often in the form of coated dosage forms provided with swellable/soluble hydrophilic polymer coatings. The latter are responsible for programmable lag phases prior to release, due to their progressive hydration in the biological fluids. When based on high-viscosity polymers and/or manufactured by press-coating, the performance of functional hydroxypropyl methylcellulose (HPMC) layers was not fully satisfactory. Particularly, it encompassed an initial phase of slow release because of outward diffusion of the drug through a persistent gel barrier surrounding the core. To promote erosion of such a barrier, the use of a cellulolytic product (Sternzym  C13030) was here explored. For this purpose, the dry mass loss behavior of tableted matrices based on various HPMC grades, containing increasing percentages of Sternzym ® C13030, was preliminarily \studied, highlighting a clear and concentration-dependent effect of the enzyme especially with high-viscosity polymers. Subsequently, Sternzym  C13030-containing systems, wherein the cellulolytic product was either incorporated into a high-viscosity HPMC coating or formed a separate underlying layer, were manufactured. Evaluated for release, such systems gave rise to more reproducible profiles, with shortened lag phases and reduced diffusional release, as compared to the reference formulation devoid of enzyme.

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Dry coating of solid dosage forms: an overview of processes and applications

Cited by 26 publications

References 107 publications

Progress of Flake Powder Metallurgy Research

Progress of Flake Powder Metallurgy Research

Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

Erodible coatings based on HPMC and cellulase for oral time-controlled release of drugs

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