Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response
Norimitsu Ban,
Ari Shinojima,
Kazuno Negishi
et al.
Abstract:Drusen are one of the most characteristic pathologies of precursor lesion of age-related macular degeneration (AMD). Drusen comprise a yellowish white substance that accumulates typically under the retinal pigment epithelium (RPE), and their constituents are lipids, complement, amyloid, crystallin, and others. In the past, many researchers have focused on drusen and tried to elucidate the pathophysiology of AMD because they believed that disease progression from early AMD to advanced AMD might be based on drus… Show more
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