Drugs–β-Cyclodextrin inclusion complex: Would be a new strategy to improve Antihypertensive Therapy?

Abstract

Taking into account the increasing use of cyclodextrins (CDs) to overcome drawbacks of drugs like antihypertensive, complex formation with of CDs seems to be a good pharmaceutical strategy to improve stability, solubility, bioavailability and reduction of side effects, thus facilitating the control of hypertension. The main objective of this short communication is to demonstrate the antihypertensive potential of complexed compounds with β-cyclodextrins and their clinical applications. This short communication identified and illustrated that β-cyclodextrin-based systems are promising sources that provide improved pharmacokinetic and formulation conditions, and important applications have been established by many research groups, optimizing β-CDs derivative systems for oral drug therapy, especially in hypertension.