Drugs which cause pain on intravenous injection

Dalgleish, D. J.

doi:10.1046/j.1365-2044.2000.01629-34.x

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…However, all previous methods need additional drugs [7,10-12,15-17], mixing solutions [13,18], and devices [14], which are not essentially required during general anesthesia induction. In addition, mixing different drugs and increasing the number of administered drugs may be potentially problematic [19]. Compared to the previously described techniques, our combination technique appears to be more practical in clinical settings because it does not require any additional device, drugs, or solutions.…”

Section: Discussionmentioning

confidence: 99%

Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children

Shin

Kim

Lee

et al. 2011

Korean J Anesthesiol

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BackgroundThe aim of this study was to evaluate whether slow injection of diluted rocuronium could reduce rocuronium-induced withdrawal movements effectively in children.MethodsAfter loss of consciousness, rocuronium 0.6 mg/kg was administered into 171 children according to the pre-assigned groups as follows: Group CF, injection of non-diluted rocuronium over 5 seconds; Group CS, injection of non-diluted rocuronium over 1 minute; Group DF, injection of diluted rocuronium (10 times) over 5 seconds; Group DS, injection of diluted rocuronium over 1 minute. An investigator who was blind to the injection techniques recorded patient movements followed by rocuronium injection.ResultsThe incidence of withdrawal movement in Group CF was highest among the groups (all P < 0.0001). Moreover, withdrawal movement was less frequently observed in Group DS than in Groups CS and DF (P = 0.021 and P = 0.007, respectively).ConclusionsSlow injection of diluted rocuronium reduced the incidence of withdrawal movements in children.

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Section: Discussionmentioning

confidence: 99%

Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children

Shin

Kim

Lee

et al. 2011

Korean J Anesthesiol

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“…Severity of pain may depend on the degree of contact with the sensitive vessel wall. The use of a large vein in the antecubital fossa minimized the injection pain caused by rocuronium [24]. The pain on injection is reduced presumably because the drug is injected into the midstream of the blood flow in the lumen of the vein, thereby minimizing its contact with the sensitive wall at high concentrations [25].…”

Section: Discussionmentioning

confidence: 99%

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Han

Koo

Choi

et al. 2007

Journal of Clinical Anesthesia

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“…rocuronium injection. Dalgleish et al [16] suggested the use of larger veins to inject rocuronium. We conducted this study using sufentanil because to date no study has been conducted using sufentanil to attenuate the pain of rocuronium injection.…”

Section: Discussionmentioning

confidence: 99%

Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine

et al. 2007

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Various strategies have been studied to reduce the discomfort of rocuronium pain. These studies have shown fentanyl and lidocaine to be effective in reducing the incidence of pain on rocuronium injection. This prospective, randomized, and double-blind study was carried out on 80 neurosurgical patients for whom pain on rocuronium injection was assessed after pretreatment with lidocaine, fentanyl, sufentanil, or normal saline. The 80 neurosurgical patients were randomly allocated to anyone of the groups to receive lidocaine, fentanyl, sufentanil, or normal saline prior to being given rocuronium. The patients were asked about any discomfort in the hand, and also to rank that discomfort on a 5-point scale. In the normal saline group, the incidence of pain was 95%, of which 90% had very severe pain. In the lidocaine group, only 10% of patients reported pain, which was mild in nature. In the fentanyl group, 95% of patients had pain, of whom 25% had severe to very severe pain. In the sufentanil group, 85% of patients reported pain, of whom 25% fell into the severe to very severe group. We found that lidocaine was best at decreasing the incidence of pain on intravenous (i.v.) injection of rocuronium. Although the incidence of pain on injection of rocuronium with both fentanyl and sufentanil was high, the intensity was definitely reduced, with most patients falling in the mild pain group.

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Drugs which cause pain on intravenous injection

Cited by 20 publications

References 5 publications

Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children

Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine

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