Drugs Repurposing for Multi-Drug Resistant Bacterial Infections

Domínguez, Andrea Vila; Me, Jiménez-Mejías; Smani, Younes

doi:10.5772/intechopen.93635

Cited by 2 publications

(1 citation statement)

References 86 publications

(198 reference statements)

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“…However, some microbial pathogens may progressively develop resistance to antimicrobial drugs due to environmental changes. This type of drug-resistant microbial pathogens is gradually increasing due to the availability of a small number of antimicrobial agents [ 56 , 57 ]. In this case, multi-targeted different variants of alternative antimicrobial drugs may be essential for effective treatment against co-/super-/secondary infections.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Kibria,

Ali,

Yaseen

et al. 2024

Pharmaceuticals

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SARS-CoV-2 infections, commonly referred to as COVID-19, remain a critical risk to both human life and global economies. Particularly, COVID-19 patients with weak immunity may suffer from different complications due to the bacterial co-infections/super-infections/secondary infections. Therefore, different variants of alternative antibacterial therapeutic agents are required to inhibit those infection-causing drug-resistant pathogenic bacteria. This study attempted to explore these bacterial pathogens and their inhibitors by using integrated statistical and bioinformatics approaches. By analyzing bacterial 16S rRNA sequence profiles, at first, we detected five bacterial genera and taxa (Bacteroides, Parabacteroides, Prevotella Clostridium, Atopobium, and Peptostreptococcus) based on differentially abundant bacteria between SARS-CoV-2 infection and control samples that are significantly enriched in 23 metabolic pathways. A total of 183 bacterial genes were found in the enriched pathways. Then, the top-ranked 10 bacterial genes (accB, ftsB, glyQ, hldD, lpxC, lptD, mlaA, ppsA, ppc, and tamB) were selected as the pathogenic bacterial key genes (bKGs) by their protein–protein interaction (PPI) network analysis. Then, we detected bKG-guided top-ranked eight drug molecules (Bemcentinib, Ledipasvir, Velpatasvir, Tirilazad, Acetyldigitoxin, Entreatinib, Digitoxin, and Elbasvir) by molecular docking. Finally, the binding stability of the top-ranked three drug molecules (Bemcentinib, Ledipasvir, and Velpatasvir) against three receptors (hldD, mlaA, and lptD) was investigated by computing their binding free energies with molecular dynamic (MD) simulation-based MM-PBSA techniques, respectively, and was found to be stable. Therefore, the findings of this study could be useful resources for developing a proper treatment plan against bacterial co-/super-/secondary-infection in SARS-CoV-2 infections.

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Section: Introductionmentioning

confidence: 99%

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Kibria,

Ali,

Yaseen

et al. 2024

Pharmaceuticals

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Superbugs: a constraint to achieving the sustainable development goals

Mohsin

Amin

2023

Bull Natl Res Cent

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Background Antimicrobial resistance has already emerged as a major concern not only for public health but also for global economy. It causes a multifaceted crisis in development and growth by increasing the number of infections and deaths. Sustainable Development Goals are in place to ensure that development and growth are continual, as well as to end poverty, protect the environment, and promote peace and prosperity. In this review we tried to highlight the reasons for the prevalence of superbugs as well as their multifaceted impact on healthcare, and demonstrate potential ways to combat them and incorporate them into international policymaking processes. Main body of the abstract The literature review included articles from MEDLINE, EMBASE, Scopus, and PubMed published till the end of the year 2022 using keyword searches. Two hundred and forty-three research articles, review papers and studies written in English language evaluating the impact of Antimicrobial resistance (AMR) on patient, society and economy published until end of the year 2022 were included. Short conclusion This review highlighted the significant impact of antimicrobial resistance (AMR) on the Sustainable Development Goals (SDGs) and was able to identify at least five SDGs that are linked to healthcare. The emergence of superbugs results in increased expenditure, which has serious consequences for the global economy, particularly in developing countries where infectious diseases are prevalent. The overuse and misuse of antibiotics, as well as poor infection control practices, are identified as primary drivers of superbug emergence. However, implementing strategies such as rational antibiotic use, effective infection control practices, and developing new antibiotics and alternative therapies can mitigate the adverse effects of AMR and contribute to achieving the SDGs. It is essential to integrate AMR strategies into national development plans and improve cross-sectoral collaboration among stakeholders to combat superbugs effectively.

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Drugs Repurposing for Multi-Drug Resistant Bacterial Infections

Cited by 2 publications

References 86 publications

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Superbugs: a constraint to achieving the sustainable development goals

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