Drugs related to the etiology of molar incisor hypomineralization

Serna, Clara; Vicente, Ascensión; Finke, Christian; Ortiz, A. S.

doi:10.1016/j.adaj.2015.08.011

Cited by 61 publications

(56 citation statements)

References 31 publications

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“…This argues for a genetic alteration causing MIH, which most typically leads to alterations confined to the enamel of first permanent molars and incisors, but on occasion can affect the enamel of adjacent teeth. The geographic differences in disease prevalence [Alaluusua et al, 1996;Dietrich et al, 2003;Kukleva et al, 2008;Wogelius et al, 2008;Soviero et al, 2009;Schmalfuss et al, 2015] and the lack of clear associations with environmental risk factors [Alaluusua, 2010;Serna et al, 2016] further support the idea that a genetic component is the best explanation for the occurrence of such interesting clinical presentation. Therefore, we propose that MIH is not an idiopathic but a genetic condition related to disturbances in the maturation stages of enamel, which in most instances in localized to first permanent molars and incisors.…”

Section: Introductionmentioning

confidence: 96%

On the Etiology of Molar-Incisor Hypomineralization

Vieira

Kup²

2016

Caries Res

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Molar-incisor hypomineralization (MIH) is a condition that is defined based on its peculiar clinical presentation. Reports on the etiology of the condition and possible risk factors are inconclusive and the original suggestion that MIH is an idiopathic condition is often cited. Our group was the first to suggest MIH has a genetic component that involves genetic variation in genes expressed during dental enamel formation. In this report, we provide a rationale to explain the preferential affection of molars and incisors. We suggest that MIH is a genetic condition based on its prevalence, which varies depending on the geographic location, and the evidence that on occasion second primary molars, permanent canines, and premolars can show signs of hypomineralization of enamel when molars and incisors are affected.

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Section: Introductionmentioning

confidence: 96%

On the Etiology of Molar-Incisor Hypomineralization

Vieira

Kup²

2016

Caries Res

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“…Moreover, currently, in the absence of identified cause(s), no risk prevention actions can be implemented (Silva, Scurrah, Craig, Manton, & Kilpatrick, ). In the past few decades, modern life factors have been postulated as aetiological factors (environmental pollutants; Jedeon et al, ; Laisi, Kiviranta, Lukinmaa, Vartiainen, & Alaluusua, ) and medications (Ghanim, Manton, Bailey, Marino, & Morgan, ; Laisi et al, ; Serna, Vicente, Finke, & Ortiz, ; Whatling & Fearne, ; Wogelius et al, ) or general factors (childhood disease [Silva et al, ; Tourino et al, ], hypoxia during birth [Garot, Manton, & Rouas, ; Tourino et al, ], and a genetic predisposition [Jeremias et al, ; Kuhnisch et al, ; Vieira & Kup, ]). However, aetiology of MIH is still unclear due to the multiplicity of causes and the nature of the majority of studies that are retrospective (Alaluusua, ; Crombie, Manton, & Kilpatrick, ).…”

Section: Introductionmentioning

confidence: 99%

Differential diagnoses of enamel hypomineralisation in an archaeological context: A postmedieval skeletal collection reassessment

Garot

Couture‐Veschambre

Manton

et al. 2019

Intl J of Osteoarchaeology

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Developmental enamel defects (DDE) are often used as indicators of general health in past archaeological populations. DDE include three common types of lesions: hypoplasia, diffuse, and demarcated opacities. Molar incisor hypomineralisation (MIH) was defined in 2001 as a qualitative enamel defect affecting first permanent molars and often permanent incisors. The European Academy of Paediatric Dentistry established criteria to diagnose MIH in current populations as demarcated white or yellow‐brown opacities of enamel with or without posteruptive breakdown. MIH is prevalent in current populations (average 14.2%) and may cause important damage to first permanent molars. Aetiological factors are uncertain. The discovery of MIH in archaeological skeletal collections based on macroscopic examination has been reported previously, in particular by Ogden and colleagues (2008). If MIH exists in past populations, there are profound implications regarding current aetiological hypotheses. Aims of the present study were to (a) reassess the London postmedieval archaeological collection from which the first cases of MIH were reported and evaluate the reliability of MIH diagnosis criteria in past populations and (b) differentially diagnose developmental defects of enamel and post mortem discoloration in the teeth. Contrary to the reported prevalence in the original study (93.2%), among 47 subadult (>18 years) individuals, a low MIH prevalence was determined (27%). Reliability of MIH diagnosis was tested with three MIH experts who were also physical anthropologists. Our study highlighted that the reliability of a macroscopic diagnosis of MIH in past populations is fair (Cohen's kappa = 0.35 ± 0.11; Fleiss's kappa = 0.3). It could explain the large differential in prevalence values in studies performed in archaeological collections. Pathological and taphonomic agents can produce enamel modifications indistinguishable from one another, even to an “experienced eye.” Here, we examined the literature to highlight potential differential diagnoses of MIH (taphonomic discoloration, amelogenesis imperfecta, fluorosis, rachitic teeth, etc.). Employing nondestructive analyses to characterise and diagnose tooth discoloration in past populations is highly recommended.

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“…Some drugs have been related to developmental enamel defects, such as opacities or hypoplasia; the most common drugs involved are chemotherapy and tetracyclines. Furthermore, penicillins have been reported to cause fluorosis and enamel hypoplasia, although it is difficult to distinguish the role of the drug from the potential effect of the fever or infection that lead to the prescription . Except for local infections and trauma, these systemic causes would usually result in generalized enamel defects instead of the localized presentation of our patients coinciding with the hemangioma site.…”

Section: Discussionmentioning

confidence: 86%