Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation

Abstract

Drugs/lamellae interface influences the inner structure of doubleloaded liposomes for inhaled anti-TB therapy: an in-depth small-angle neutron scattering investigation,

Understanding the Temperature‐Responsive Self‐Assemblies of Amphiphilic Random Copolymers by SANS in D2O Solution

“…SANS methodology [13][14][15] offers an opportunity to enrich and eventually clarify the information available in this context. The high contrast and adequate resolution of this technique enables to follow the form factor, the surface, the stability, and reversibility features that testify to the conformational change of the PEGMA-co-FA self-assemblies when they are either individually self-folded in unimers with a nanometric scale length (so called unimer micelles) or clustered together into aggregates with micro-sized super-structures.…”

Influence of drug/lipid interaction on the entrapment efficiency of isoniazid in liposomes for antitubercular therapy: a multi-faced investigation

“…To sum sup, our findings indicate the presence of druglipid attractive interactions, strongly suggesting the occurrence of INH adsorption at the lipid interface [30] and point out the relevant role of lipid organization. As argued by Truzzi et al [17] in PC-Chol multilamellar vesicles, drug adsorption could be originated by the presence of a certain drug-lipid affinity. Hereafter we will show that this is indeed what occurs in our formulations, corroborating this finding by an extensive characterization of the organization of lipid layer and its interaction with INH.…”

“…A further boost to the use of multilamellar vesicles has been given by the possibility to co-encapsulate two anti-TB drugs as rifampicin and INH. The lipophilic rifampicin can be entrapped in the bilayers enclosing adjacent aqueous compartments, where INH is dispersed [13,17]. Moreover, since the penetration depth of liposomes administered to the lungs through inhalation depends on the size of the particles in the aerosol, and particles with diameters ranging from 0.1 to 2 µm can be effectively transported to the alveoli [5,14], multilamellar vesicles are still under consideration.…”

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

“…Although the investigation of new pharmaceutical forms for the delivery of current antitubercular drugs may contribute to enhance patient compliance and limit the spread of the disease [2,3], the development of new therapeutic options represents an even more pressing need. While drug-susceptible TB can be cured within 6-8 months with the current standard treatment regimen [4], multi-and extensively drug-resistant (MDR/XDR) infections are treated for at least 20 months with poor outcomes [5], posing a serious threat to human health.…”