Drugs in Tuberculosis and Leprosy

Ramanathan, Meenakshi; Howell, Crystal K.; Sanders, James M.

doi:10.1016/bs.seda.2018.06.014

Cited by 6 publications

(2 citation statements)

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“…It is a component of the Terizidone formulation and works by inhibiting the formation of bacterial cell walls by specifically targeting enzymes that are essential for peptidoglycan synthesis, such as alanine racemase (AlrA) and D-alanine ligase. The medication prevents bacteria from manufacturing their cell walls by interfering with these mechanisms [108][109][110]. Additionally, cyclorine inhibits the activities of alanine permease and Dalanyl-D-alanine synthetase, weakening the bacterial cell wall and causing bacterial cell death [111].…”

Section: Ethambutolmentioning

confidence: 99%

Navigating the Challenge of Tuberculosis Drug Resistance: Unveiling Intrinsic and Acquired Pathways to Overcome the Threat

Aslam,

Sharif,

Uroos

et al. 2024

J. Adv. Microbiol.

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Tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis (MTB), continues to be a persistent worldwide health problem, made worse by the appearance of strains that are resistant to drugs. This review thoroughly examines the complex phenomenon of drug resistance in TB, investigating both the intrinsic characteristics and acquired changes that contribute to the bacterial ability to withstand treatment. It explores the progression of tuberculosis treatment, starting with the basic medications that target cell wall formation, then moving on to more advanced tactics that overcome resistance. It also discusses the new third-line therapies, providing insights into the dynamic landscape of TB treatment. Considering the increasing prevalence of multidrug-resistant and extensively drug-resistant strains, it is crucial to adopt innovative strategies. These may involve altering existing antibiotics, investigating new chemicals, and gaining a more comprehensive understanding of new targets. This review emphasizes the need of knowing MTB medication resistance mechanisms that will enhance our understanding of MTB medication resistance and prepares us for future study, providing insights and approaches to address this global health issue more effectively.

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Section: Ethambutolmentioning

confidence: 99%

Navigating the Challenge of Tuberculosis Drug Resistance: Unveiling Intrinsic and Acquired Pathways to Overcome the Threat

Aslam,

Sharif,

Uroos

et al. 2024

J. Adv. Microbiol.

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“…Despite the effectiveness of BDQ and delamanid, a startling rate of resistance shortly after its launch was observed, especially for BDQ [33,34,243]. Currently, cautious use of BDQ and delamanid is in play due to the possibility of cardiotoxicity [244,245].…”

Section: Drug Repurposingmentioning

confidence: 99%

Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome BCC oxidase for tuberculosis disease

Chong¹

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My heart is filled with gratitude to everyone who have accompanied me through my PhD journey. The completion of this research would not have been possible without the contribution of many individuals.First and foremost, I would like to extend my sincerest gratitude to my main supervisor, Prof.Gerhard Grüber. His valuable advice, encouragement, and insightful comments have provided a rewarding learning experience. I appreciate the life lessons, many of which will be carried with me throughout my whole life. I am extremely grateful to Prof. Roderick Wayland Bates. Prof. Bates first sparked my interest in research during my first year of my undergraduate studies. His patience, immense knowledge, and unwavering support have played a big role to where I am today.I would like to thank my mentor, Prof. Thomas Dick, and Prof. Kevin Pethe, for their valuable suggestions and advice. Special thanks to their students, Mr. Jickky Palmae Sarathy, Ms. Lee Bei Shi, and Ms. Ekaterina Sviriaeva, for the enjoyable moments where we exchanged ideas and experiences.

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