“…Rather, in our opinion, the study adds to the extant literature indicating that female sexuality is not readily modifiable via agents. In this regard, whereas some studies have found improvements in sexual function following administration of saffron [55], tribulus terrestris [56], and flibanserin [57] for women suffering from hypoactive sexual desire disorder or SSRI-I SD, and whereas efforts are being made to identify new avenues to improve women's hyposexual function or SSRI-I SD [58], it remains unclear to what extent previous findings have found improvements but without achieving full remission to normal levels of sexual desire. In this context, given a tendency not to publish zero effects, it is also unclear whether the small number of publications reporting a favorable effect of agents on females' sexual function reflects this form of publication bias.…”