Drugs for Control of American Foulbrood of Honey Bee

Hayama, Toyoaki; Okayama, Akira; Nakajima, Chie; Sumitomo, Tomoko; Kataoka, Shigeaki; Nakamura, Akira

doi:10.12935/jvma1951.50.429

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“…The primary food of larvae at this stage is worker or royal jelly, and larvae receive MRM from nurse bees via the jelly. MRM exerts bacteriostatic and bacteriocidal effects against the vegetative cells of P. larvae (Hayama et al, 1997) and is expected to suppress clinical symptoms by controlling the proliferation of vegetative cells in larvae. However, this drug is ineffective against P. larvae spores and cannot be expected to eliminate spores from hives (https://www.feed-one.co.jp/ business/specialty/pdf/qanda.pdf).…”

Section: Afb Cases In Apiaries Where Mrm Was Usedmentioning

confidence: 99%

Population structure and antimicrobial susceptibility of Paenibacillus larvae isolates from American foulbrood cases in Apis mellifera in Japan

Ueno

Yoshida

Misumi³

et al. 2018

Environ Microbiol Rep

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Paenibacillus larvae is the causative agent of American foulbrood (AFB), the most destructive disease of the honey bee brood. In this study, we investigated the population structure and antimicrobial susceptibility of Japanese P. larvae using 100 isolates isolated between 1993 and 2017 in 17 prefectures. Using repetitive-element PCR and multilocus sequence typing, isolates from diverse origins were classified into six genotypes, including the novel genotype ERIC II-ST24. Among these genotypes, ERIC I-ST15 is the most common in Japan, while ERIC II-ST10 isolates were found to be increasing during the 2010s. Regardless of genotype or origin, all isolates were susceptible to the major antimicrobials used in the control of AFB, including mirosamicin and tylosin, which were approved for the prevention of AFB in Japan in 1999 and 2017 respectively. Despite nearly 20 years of use, mirosamicin is still effective against Japanese P. larvae in vitro; however, the development of AFB in honey bee colonies may not always be suppressed by this drug. The case information collected in this study provides insight into the conditions under which prophylactic medicine may not exert sufficient preventive effects in vivo.

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Section: Afb Cases In Apiaries Where Mrm Was Usedmentioning

confidence: 99%