Drugs for bone healing

Brandi, Maria Luisa

doi:10.1517/13543784.2012.696610

Cited by 27 publications

(16 citation statements)

References 70 publications

(14 reference statements)

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“…Attempts to change the abnormal occurrence of fracture mostly in at-risk patients focus on local interventions, and the systemic drugs have been overlooked. However, the interest in such drugs has increased due to promising results for bone healing 26 . Several preclinical studies have demonstrated the positive impact of both anti-catabolic and anabolic drugs on fracture healing in osteoporotic bone models 25 .…”

Section: ■ Discussionmentioning

confidence: 99%

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Guimarães

Butezloff²,

Zamarioli³

et al. 2017

Acta Cir. Bras.

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Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture 1 AbstractPurpose: To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats. Methods: Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate. Fractures were created at the mid-diaphysis of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire. The DN was injected intramuscularly twice per week (10 mg/kg of body mass). The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia. The newly formed bone and collagen type I levels were quantified in the callus. Results:The treated animals had longer femurs after 28 days. The quality of the intact bone was not significantly different between groups. The bone callus did show a larger mass in the treated rats. Conclusion:The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.

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Section: ■ Discussionmentioning

confidence: 99%

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Guimarães

Butezloff²,

Zamarioli³

et al. 2017

Acta Cir. Bras.

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“…Pharmacological interventions that could modulate the healing process positively have been recently merged to the treatment algorithm, where systemic anti-osteoporosis drugs are considered the additional contributing factor [8]. The role of systemic drug therapies in long bones fracture healing remains limited, although the use several anabolic agents has reported positive results in selected shaft fractures types, such as atypical femoral fractures, periprosthetic femoral fractures and recalcitrant non-unions [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence

et al. 2020

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Background: The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the healing process, such as scaffolds, growth factors, cell therapies and systemic pharmacological treatments. Our aim was to investigate the current evidence of bone healing enhancement of acute long bone diaphyseal fractures. Methods: A systematic review was conducted by using Pubmed/MEDLINE; Embase and Ovid databases. The combination of the search terms “long-bones; diaphyseal fracture; bone healing; growth factors; cell therapies; scaffolds; graft; bone substitutes; orthobiologics; teriparatide”. Results: The initial search resulted in 4156 articles of which 37 papers fulfilled the inclusion criteria and were the subject of this review. The studies included 1350 patients (837 males and 513 females) with a mean age of 65.3 years old. Conclusions: General lack of high-quality studies exists on the use of adjuvant strategies for bone healing enhancement in acute shaft fractures. Strong evidence supports the use of bone grafts, while only moderate evidence demineralized bone matrix and synthetic ceramics. Conflicting results partially supported the use of growth factors and cell therapies in acute fractures. Teriparatide showed promising results, particularly for atypical femoral fractures and periprosthetic femoral fractures.

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“…16,22 Consequently, research efforts currently widely use preclinical models to reveal effective strategies for the delivery of antiosteoporotic drugs to a bone defect in both healthy and osteoporotic conditions. 23,24 There are a number of antiosteoporotic drugs that have anticatabolic effects (mainly bisphosphonates [BPs], calcitonin, and estrogen therapy). [23][24][25] The anticatabolic drugs can help to limit bone loss by decreasing osteoclastic activity.…”

Section: Introductionmentioning

confidence: 99%

“…23,24 There are a number of antiosteoporotic drugs that have anticatabolic effects (mainly bisphosphonates [BPs], calcitonin, and estrogen therapy). [23][24][25] The anticatabolic drugs can help to limit bone loss by decreasing osteoclastic activity. The second group of antiosteoporotic drugs (i.e., anabolic agents) is expected to promote rapid bone formation, including parathyroid hormone (PTH), strontium ranelate, and simvastatin.…”

Section: Introductionmentioning

confidence: 99%

“…The second group of antiosteoporotic drugs (i.e., anabolic agents) is expected to promote rapid bone formation, including parathyroid hormone (PTH), strontium ranelate, and simvastatin. [22][23][24]26 Mainly, statins are the drugs of choice in controlling high levels of cholesterol by inhibiting a specific enzyme (i.e., 3-hydroxy-3methylglutaryl coenzyme A [HMG-CoA] reductase). 27,28 Recently, several studies have explored an anabolic effect of statins on bone healing.…”

Section: Introductionmentioning

confidence: 99%

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Bone Regeneration Using Antiosteoporotic Drugs in Adjunction with Bone Grafting: A Meta-Analysis

Shaheen

Basudan

Vries

et al. 2019

Tissue Engineering Part B: Reviews

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The aim of this review was to systematically assess bone regeneration by using antiosteoporotic drugs in adjunction with bone grafting compared with controls (bone grafting without the administration of antiosteoporotic drugs). The review also evaluated statistical differences in the effect between systemic and local routes of drugs. Also, the effect of type of drugs (anticatabolic vs. anabolic) was subevaluated. PubMed and EMBASE (via OvidSP) resulted in inclusion of 60 animal studies. The studies were assessed for reporting quality and risk of bias. Outcome data from selected studies were categorized as either experimental (bone grafting with the administration of antiosteoporotic drugs) or control. Meta-analysis of selected studies was done for these outcomes: histomorphometrical bone area (BA%) and micro-CT bone volume (BV%). In this review, several animal models (52 healthy, 6 osteoporotic, and 2 both conditions) were subjected to examine the effect of antiosteoporotic drugs on bone grafting, with a predominant use of rodent species. Assessment indicates poor reporting quality and unclear risk of bias in the majority of studies. Random-effects metaanalysis revealed a significant increase in overall BA% (mean difference [MD]: 2.6, confidence interval [CI]: 2.25 to 2.92) and BV% (MD: 0.12, CI: 0.05 to 0.19) due to osteoporotic drug treatment compared with controls. For subgroups, both routes of antiosteoporotic drug administration showed similar effects on BA%. In contrast, systemic antiosteoporotic drug administration led to significantly higher BV% (MD: 6.75, CI: 5.30 to 8.19) compared with local administration (MD: 0.02, CI: -0.03 to 0.08). Further, administration of anabolic drugs significantly increased BA% (MD: 5.75, CI: 4.62 to 6.87) compared with anticatabolic drugs (MD: 1.86, CI: 1.47 to 2.26). In conclusion, both histomorphometrical and micro-CT scan analysis indicated an overall effect of using the antiosteoporotic drugs toward bone regeneration in adjunction with grafting. However, not all studies showed a positive effect and the present results need to be applied with care, as the included papers showed experimental heterogeneity for animal models. Further (pre)clinical research is warranted to explore whether drug-based strategies can be an effective adjunctive with bone grafting.The aim of this meta-analysis was to assess whether antiosteoporotic drugs can promote bone regeneration in adjunction with bone grafting by using preclinical animal models. Although the majority of included studies indicated poor reporting quality and unclear risk of bias, an overall positive effect of the antiosteoporotic drugs toward bone regeneration related to bone grafts can be highlighted.

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Drugs for bone healing

Cited by 27 publications

References 70 publications

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence

Bone Regeneration Using Antiosteoporotic Drugs in Adjunction with Bone Grafting: A Meta-Analysis

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