Drugs Containing Snake Venom: History of Development, Nomenclature, Identification

Григорьева, Валерия; Гунар, О. В.; Сахно, Н. Г.; Булгакова, Г М; Молчан, Н В

doi:10.30895/1991-2919-2018-8-2-

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Decades ago, crotamine, a low molecular weight cationic membrane active peptide [16], was first isolated from the venom of Argentinean rattlesnakes [17]. Subsequently, crotamine (Table 1) was found to consist of forty-two amino acid residues, including nine lysine, two arginine, and six cysteine residues that are interconnected via three disulfide bridges [18].…”

Section: Cpps From Snake Venommentioning

confidence: 99%

“…More recently, researchers exploring clinical applications of crotamine via biodistribution studies have reported that crotamine antitumor activity requires homing of the molecule to tumor cell nuclei [19], while other researchers have reported crotamine antimicrobial activities [16]. Even though crotamine has promise as a clinically useful agent, local and systemic acute inflammatory responses can be triggered by intradermal injection of the natural form of the peptide into rats, which has limited its therapeutic applicability [17]. To address this issue, since 2020, crotamine-based cell-penetrating nanocarriers have been developed as delivery systems for use in introducing nucleic acids into cells and animals.…”

Section: Cpps From Snake Venommentioning

confidence: 99%

“…Furthermore, R-lycosin-I (Table 1) penetrated deeper into 3D tumor spheroids and exhibited stronger tumor inhibitory activity and greater serum stability than lycosin-I when incubated with solid tumor cells [39]. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] RhB-KKRLKKIFKKPMVIGVTIPF-NH 2 Ctn [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]-Lys(RhB) KKRLKKIFKKPMVIGVTIPFK(RhB)-NH 2 CF-Ctn [17][18][19][20][21][22][23][24]…”

Section: Cpps From Spider Venommentioning

confidence: 99%

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Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

Zhang

et al. 2023

Pharmaceutics

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Peptides and proteins, two important classes of biomacromolecules, play important roles in the biopharmaceuticals field. As compared with traditional drugs based on small molecules, peptide- and protein-based drugs offer several advantages, although most cannot traverse the cell membrane, a natural barrier that prevents biomacromolecules from directly entering cells. However, drug delivery via cell-penetrating peptides (CPPs) is increasingly replacing traditional approaches that mediate biomacromolecular cellular uptake, due to CPPs’ superior safety and efficiency as drug delivery vehicles. In this review, we describe the discovery of CPPs, recent developments in CPP design, and recent advances in CPP applications for enhanced cellular delivery of peptide- and protein-based drugs. First, we discuss the discovery of natural CPPs in snake, bee, and spider venom. Second, we describe several synthetic types of CPPs, such as cyclic CPPs, glycosylated CPPs, and D-form CPPs. Finally, we summarize and discuss cell membrane permeability characteristics and therapeutic applications of different CPPs when used as vehicles to deliver peptides and proteins to cells, as assessed using various preclinical disease models. Ultimately, this review provides an overview of recent advances in CPP development with relevance to applications related to the therapeutic delivery of biomacromolecular drugs to alleviate diverse diseases.

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Section: Cpps From Snake Venommentioning

confidence: 99%

Section: Cpps From Snake Venommentioning

confidence: 99%

Section: Cpps From Spider Venommentioning

confidence: 99%

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Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

Zhang

et al. 2023

Pharmaceutics

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Clinical Blood Parameters of Rats With Chronic Inflammation of the Soft Tissues of the Back During a Course of Intramuscular Injection of Solutions of the Transcaucasian Viper Venom (Macrovipera Lebetina Obtusa)

U.E.,

E.F.

2024

Vestnik "Biomedicina i sociologiya"

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An relevant task of modern pharmacology is the search for drugs for the treatment of chronic inflammatory processes. The use of nonsteroidal anti-inflammatory drugs and drugs of the glucocorticoid group has a number of limitations due to pronounced negative effects. The use of herbal anti-inflammatory drugs often has a delayed effect. In this case, the anti-inflammatory effect is manifested in the later stages of the pathological process. For this reason, it seems interesting to us to use a solution of poison obtained from gyurza (Macrovipera lebetina obtusa) as an alternative therapy for chronic inflammatory processes. Earlier in our work, the ability of solutions of these poisons to reduce inflammation was shown. This effect was found both in native venom solutions and in those heated to 55оС. In this work, the effect of venom solutions was studied after a course of intramuscular administration. The criteria for anti-inflammatory action were blood counts in experimental chronic inflammation caused by acetic acid. Inflammation was modeled by injecting 0.5 ml of 9% acetic acid solution under the skin of the back and intraperitoneal administration of 1 ml of 10% Rheopolyglukin solution to white outbred male rats. Diclofenac in injections was chosen as a comparison drug. The assessment of clinical blood parameters was carried out on an automatic hematology analyzer BC 2800vet (Mindray). The positive dynamics of the course of the chronic aseptic inflammatory process has been revealed. A more positive dynamics of the course of the chronic aseptic inflammatory process was revealed in groups of animals receiving solutions of native venom.

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Drugs Containing Snake Venom: History of Development, Nomenclature, Identification

Cited by 2 publications

References 10 publications

Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

Clinical Blood Parameters of Rats With Chronic Inflammation of the Soft Tissues of the Back During a Course of Intramuscular Injection of Solutions of the Transcaucasian Viper Venom (Macrovipera Lebetina Obtusa)

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